Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 1/20 | 0.36 |
| ▸ | CCR4 | P51679 | 6/20 | 0.35 |
| ▸ | FPR2 | P25090 | 1/20 | 0.35 |
| ▸ | EIF2AK3 | Q9NZJ5 | 1/20 | 0.34 |
| ▸ | CNR1 | P21554 | 3/20 | 0.34 |
| ▸ | CNR2 | P34972 | 3/20 | 0.34 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | SRC | P12931 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4008416 | 0.84 | CCR4 (0.39) | CCR4EIF2AK3CNR2P2RX7KMT2A | |
| SCHEMBL4002268 | 0.79 | CNR1 (0.36) | FPR2EIF2AK3CNR1CNR2P2RX7 | |
| SCHEMBL13769680 | 0.79 | MAPK14 (0.40) | CCR4EIF2AK3P2RX7KDM4EALDH1A1 | |
| SCHEMBL4007105 | 0.78 | ADK (0.40) | FPR2P2RX7KDM4EALDH1A1KMT2A | |
| SCHEMBL13769532 | 0.78 | PDE4B (0.41) | P2RX7KDM4EALDH1A1KMT2ASRC | |
| SCHEMBL4012559 | 0.76 | CCR4 (0.40) | CCR4EIF2AK3P2RX7SRC | |
| SCHEMBL19208112 | 0.75 | CFD (0.37) | FPR2P2RX7KDM4EALDH1A1KMT2A | |
| SCHEMBL4007615 | 0.74 | SRC (0.43) | CCR4P2RX7KMT2ASRCMEN1 | |
| SCHEMBL4013000 | 0.74 | CCR4 (0.39) | CCR4P2RX7 | |
| SCHEMBL25542303 | 0.74 | FPR2 (0.33) | FPR2KDM4EALDH1A1KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009080682-A1 | PYRROLO[2,3-D]PYRIMIDINE DERIVATIVES AS CGRP RECEPTOR ANTAGONISTS | GLAXO GROUP LIMITED (GB) | 2009-07-02 | — | — | WO | disclosed |
| WO-2009080682-A1 | PYRROLO[2,3-D]PYRIMIDINE DERIVATIVES AS CGRP RECEPTOR ANTAGONISTS | GLAXO GROUP LIMITED (GB) | 2009-07-02 | — | — | WO | disclosed |