Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR4 | P51679 | 5/20 | 0.40 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.35 |
| ▸ | P2RX7 | Q99572 | 4/20 | 0.32 |
| ▸ | FLT3 | P36888 | 1/20 | 0.32 |
| ▸ | EIF2AK3 | Q9NZJ5 | 1/20 | 0.32 |
| ▸ | KMO | O15229 | 1/20 | 0.32 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.32 |
| ▸ | CFD | P00746 | 1/20 | 0.31 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.31 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.31 |
| ▸ | SRC | P12931 | 1/20 | 0.31 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.31 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.31 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.31 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.31 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.31 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13769680 | 0.87 | MAPK14 (0.40) | CCR4P2RX7EIF2AK3MAPK14 | |
| SCHEMBL4008416 | 0.85 | CCR4 (0.39) | CCR4MCL1P2RX7EIF2AK3KMO | |
| SCHEMBL4013000 | 0.83 | CCR4 (0.39) | CCR4MCL1P2RX7KMOPTGDR2 | |
| SCHEMBL4009501 | 0.76 | SCN9A (0.36) | CCR4P2RX7EIF2AK3SRC | |
| SCHEMBL4007615 | 0.75 | SRC (0.43) | CCR4MCL1P2RX7SRC | |
| SCHEMBL4007097 | 0.74 | ALOX15 (0.36) | CCR4MCL1PTGDR2SRC | |
| SCHEMBL4014280 | 0.74 | EGLN1 (0.34) | CCR4MCL1P2RX7PTGDR2SRC | |
| SCHEMBL13769710 | 0.74 | KCNH2 (0.40) | — | |
| SCHEMBL13769716 | 0.74 | CALCRL (0.56) | — | |
| SCHEMBL4008754 | 0.73 | FLT4 (0.44) | CCR4MCL1EIF2AK3SRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009080682-A1 | PYRROLO[2,3-D]PYRIMIDINE DERIVATIVES AS CGRP RECEPTOR ANTAGONISTS | GLAXO GROUP LIMITED (GB) | 2009-07-02 | — | — | WO | disclosed |