Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 3/20 | 0.47 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | CASP1 | P29466 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | HTR2B | P41595 | 1/20 | 0.41 |
| ▸ | PLAAT3 | P53816 | 2/20 | 0.40 |
| ▸ | PLAAT5 | Q96KN8 | 2/20 | 0.40 |
| ▸ | PLAAT2 | Q9NWW9 | 2/20 | 0.40 |
| ▸ | PLAAT4 | Q9UL19 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27763495 | 0.85 | HTR2C (0.41) | HTR2CHTR2B | |
| SCHEMBL18142154 | 0.85 | CTSC (0.49) | HTR2CEPHX1ALDH1A1HTR2BPOLB | |
| SCHEMBL21540823 | 0.80 | HTR2C (0.60) | HTR2CEPHX1ALDH1A1CASP1HSD17B10 | |
| SCHEMBL4677228 | 0.77 | EPHX2 (0.49) | HTR2CEPHX1HTR2BPLAAT3PLAAT5 | |
| SCHEMBL15126141 | 0.75 | HTR2C (0.77) | HTR2CEPHX1HTR2B | |
| SCHEMBL6099087 | 0.75 | EPHX1 (0.50) | HTR2CEPHX1HTR2BPLAAT3PLAAT5 | |
| SCHEMBL7546748 | 0.75 | HTR2C (0.77) | HTR2CEPHX1HTR2B | |
| SCHEMBL14304107 | 0.73 | CCR1 (0.49) | HTR2CALDH1A1 | |
| SCHEMBL18589371 | 0.73 | MGLL (0.44) | HTR2CALDH1A1 | |
| SCHEMBL18607990 | 0.73 | MGLL (0.44) | HTR2CALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009082526-A2 | ORTHO PYRROLIDINE, BENZYL-SUBSTITUTED HETEROCYCLE CCR1 ANTAGONISTS FOR AUTOIMMUNE DISEASES & INFLAMMATION | PHARMACOPEIA, INC. (US) | 2009-07-02 | — | — | WO | disclosed |