Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPM8 | Q7Z2W7 | 7/20 | 0.49 |
| ▸ | HTR2C | P28335 | 3/20 | 0.36 |
| ▸ | HTR2B | P41595 | 1/20 | 0.36 |
| ▸ | ADRA2A | P08913 | 3/20 | 0.36 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.36 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.36 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.36 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.36 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.36 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.36 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.36 |
| ▸ | DRD2 | P14416 | 1/20 | 0.34 |
| ▸ | HTR2A | P28223 | 1/20 | 0.34 |
| ▸ | AHR | P35869 | 2/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.33 |
| ▸ | PNMT | P11086 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL537759 | 0.84 | HTR2C (0.50) | TRPM8HTR2CHTR2BADRA2ATAAR1 | |
| Hydrochloric Acid SCHEMBL3708253 | 0.83 | HTR2C (0.49) | TRPM8HTR2CHTR2BADRA2ATAAR1 | |
| Hydrochloric Acid SCHEMBL10502448 | 0.72 | HTR2C (0.39) | TRPM8HTR2CHTR2BSIGMAR1HTR2A | |
| SCHEMBL619893 | 0.71 | TRPM8 (0.54) | TRPM8SIGMAR1 | |
| SCHEMBL4445219 | 0.71 | TRPM8 (0.44) | TRPM8 | |
| SCHEMBL30376964 | 0.71 | SIGMAR1 (0.57) | TRPM8HTR2CADRA1DADRA1AADRA1B | |
| SCHEMBL2077983 | 0.71 | SIGMAR1 (0.57) | TRPM8HTR2CADRA1DADRA1AADRA1B | |
| SCHEMBL919159 | 0.70 | TRPM8 (0.38) | TRPM8HTR2CHTR2BHTR2A | |
| SCHEMBL3800669 | 0.70 | TRPM8 (0.38) | TRPM8HTR2CHTR2BHTR2A | |
| SCHEMBL3797219 | 0.70 | TRPM8 (0.38) | TRPM8HTR2CHTR2BHTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009084034-A2 | CHROMANE DERIVATIVES AS TRPV3 MODULATORS | GLENMARK PHARMACEUTICALS, S. A. (CH) | 2009-07-09 | — | — | WO | disclosed |