Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 6/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.48 |
| ▸ | GLO1 | Q04760 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 6/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 2/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
| ▸ | PKLR | P30613 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | ATM | Q13315 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1378007 | 0.95 | HSD11B1 (0.55) | HSD11B1MEN1KMT2ATDP1GLO1 | |
| SCHEMBL1379633 | 0.80 | KDM4E (0.50) | HSD11B1TDP1GLO1LMNAKDM4E | |
| SCHEMBL1377807 | 0.79 | HSD11B1 (0.54) | HSD11B1MEN1KMT2ALMNAKDM4E | |
| SCHEMBL29227870 | 0.78 | HSD11B1 (0.59) | HSD11B1MEN1KMT2ATDP1GLO1 | |
| SCHEMBL30939457 | 0.78 | HSD11B1 (0.59) | HSD11B1MEN1KMT2ATDP1GLO1 | |
| SCHEMBL1377739 | 0.76 | GLO1 (0.54) | MEN1KMT2AGLO1LMNAKDM4E | |
| SCHEMBL1379254 | 0.76 | HSD11B1 (0.60) | HSD11B1MEN1KMT2ATDP1GLO1 | |
| SCHEMBL1378609 | 0.75 | HSD11B1 (0.59) | HSD11B1MEN1KMT2ATDP1GLO1 | |
| SCHEMBL9942079 | 0.73 | KDM4E (0.68) | HSD11B1MEN1KMT2ATDP1GLO1 | |
| SCHEMBL1381599 | 0.72 | ALDH1A1 (0.50) | MEN1KMT2ALMNAKDM4EMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-4809339-B2 | — | — | 2011-11-09 | — | — | JP | claimed |
| EP-1763517-B1 | PYRIMIDINE DERIVATIVES AS 11BETA-HSD1 INHIBITORS | HOFFMANN LA ROCHE (CH) | 2011-05-11 | — | — | EP | claimed |
| EP-1763517-B1 | PYRIMIDINE DERIVATIVES AS 11BETA-HSD1 INHIBITORS | HOFFMANN LA ROCHE (CH) | 2011-05-11 | — | — | EP | disclosed |