Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHFR | P00374 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | CA12 | O43570 | 1/20 | 0.40 |
| ▸ | CA1 | P00915 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 1/20 | 0.40 |
| ▸ | CA9 | Q16790 | 1/20 | 0.40 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | IDO1 | P14902 | 2/20 | 0.39 |
| ▸ | GHSR | Q92847 | 2/20 | 0.39 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13788810 | 0.82 | PIK3CD (0.43) | POLBCA12CA1CA2CA9 | |
| SCHEMBL4488885 | 0.78 | ALDH1A1 (0.52) | DHFRMAPTGAA | |
| SCHEMBL5149849 | 0.69 | MAPT (0.57) | POLBCA12CA1CA2CA9 | |
| SCHEMBL12495756 | 0.68 | KDM4E (0.54) | POLBCA12CA1CA2CA9 | |
| Bromide SCHEMBL21382416 | 0.68 | MAPT (0.60) | POLBCA12CA1CA2CA9 | |
| SCHEMBL10569845 | 0.67 | LMNA (0.53) | DHFRPOLBCA12CA1CA2 | |
| SCHEMBL4834106 | 0.66 | ALDH1A1 (0.50) | POLBMAPTGAAIDO1LOXL2 | |
| SCHEMBL28907414 | 0.66 | POLB (0.53) | POLBCA12CA1CA2CA9 | |
| SCHEMBL30041078 | 0.66 | POLB (0.53) | POLBCA12CA1CA2CA9 | |
| SCHEMBL28756594 | 0.65 | CA1 (0.60) | CA1CA2CA9MAPTGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7560552-B2 | Thiopyrimidine and isothiazolopyrimidine kinase inhibitors | ABBOTT LABORATORIES (US) | 2009-07-14 | — | — | US | disclosed |