Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 9/20 | 0.66 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.66 |
| ▸ | HPGD | P15428 | 3/20 | 0.66 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.56 |
| ▸ | MEN1 | O00255 | 5/20 | 0.56 |
| ▸ | NPC1 | O15118 | 5/20 | 0.56 |
| ▸ | RAB9A | P51151 | 5/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.56 |
| ▸ | POLB | P06746 | 2/20 | 0.56 |
| ▸ | LMNA | P02545 | 2/20 | 0.56 |
| ▸ | CASP3 | P42574 | 1/20 | 0.56 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.56 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.56 |
| ▸ | TP53 | P04637 | 2/20 | 0.52 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.52 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.52 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.51 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL946592 | 0.82 | KDM4E (0.66) | KDM4EALDH1A1HPGDSMN1; SMN2MEN1 | |
| SCHEMBL1912122 | 0.81 | KDM4E (0.54) | KDM4EALDH1A1HPGDSMN1; SMN2MEN1 | |
| SCHEMBL5365142 | 0.81 | KDM4E (0.65) | KDM4EALDH1A1HPGDSMN1; SMN2MEN1 | |
| SCHEMBL45762 | 0.79 | KDM4E (0.60) | KDM4EALDH1A1HPGDSMN1; SMN2MEN1 | |
| SCHEMBL30139987 | 0.79 | KDM4E (0.60) | KDM4EALDH1A1HPGDSMN1; SMN2MEN1 | |
| SCHEMBL12172767 | 0.79 | ALDH1A1 (1.00) | KDM4EALDH1A1HPGDSMN1; SMN2MEN1 | |
| SCHEMBL1409830 | 0.77 | KDM4E (0.64) | KDM4EALDH1A1HPGDSMN1; SMN2MEN1 | |
| SCHEMBL8640120 | 0.77 | SMN1; SMN2 (0.79) | KDM4EALDH1A1HPGDSMN1; SMN2MEN1 | |
| SCHEMBL8640127 | 0.77 | SMN1; SMN2 (0.79) | KDM4EALDH1A1HPGDSMN1; SMN2MEN1 | |
| SCHEMBL894741 | 0.76 | SIRT2 (0.70) | KDM4EALDH1A1HPGDSMN1; SMN2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7560464-B2 | Polycyclic pyrimidines as potassium ion channel modulators | ICAGEN, INC. (US) | 2009-07-14 | — | — | US | disclosed |