Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 10/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.60 |
| ▸ | POLB | P06746 | 2/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.57 |
| ▸ | HPGD | P15428 | 2/20 | 0.57 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.56 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.56 |
| ▸ | LMNA | P02545 | 2/20 | 0.54 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.51 |
| ▸ | TP53 | P04637 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 5/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.50 |
| ▸ | NPC1 | O15118 | 3/20 | 0.50 |
| ▸ | RAB9A | P51151 | 3/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | PKM | P14618 | 1/20 | 0.50 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.50 |
| ▸ | CASP3 | P42574 | 1/20 | 0.49 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30139987 | 1.00 | KDM4E (0.60) | KDM4ESMN1; SMN2POLBALDH1A1HPGD | |
| SCHEMBL233797 | 0.86 | KMT2A (0.57) | KDM4ESMN1; SMN2POLBALDH1A1HPGD | |
| Benzene SCHEMBL27690342 | 0.86 | KMT2A (0.57) | KDM4ESMN1; SMN2POLBALDH1A1HPGD | |
| SCHEMBL7313744 | 0.86 | KDM4E (0.46) | KDM4ESMN1; SMN2POLBALDH1A1HPGD | |
| SCHEMBL5365142 | 0.85 | KDM4E (0.65) | KDM4ESMN1; SMN2POLBALDH1A1HPGD | |
| SCHEMBL9302227 | 0.85 | KMT2A (0.49) | KDM4ESMN1; SMN2POLBALDH1A1HPGD | |
| Hydrochloric Acid SCHEMBL6013658 | 0.85 | KMT2A (0.55) | KDM4ESMN1; SMN2POLBALDH1A1HPGD | |
| SCHEMBL10816174 | 0.83 | KDM4E (0.42) | KDM4ESMN1; SMN2POLBALDH1A1HPGD | |
| Hydrochloric Acid SCHEMBL11793085 | 0.83 | KDM4E (0.46) | KDM4ESMN1; SMN2POLBALDH1A1HPGD | |
| SCHEMBL11760578 | 0.83 | GAA (0.61) | KDM4ESMN1; SMN2POLBALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 69 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115997016-A | Composition comprising nucleic acid nanoparticles having modular functional groups | 西克斯福德生物科学有限公司 | 2023-04-21 | — | — | CN | claimed |
| US-20060148901-A1 | Acylated 4-amidino-and-4-guanidinobenzylamines for inhibition of plasma kallikrein | THE MEDICINES COMPANY (LEIPZIG) GMBH (DE) | 2006-07-06 | — | — | US | claimed |
| CN-1168707-C | 4-guanidinobenzamides antifertility compounds | 中国人民解放军第二军医大学 | 2004-09-29 | — | — | CN | claimed |
| CN-1401634-A | 4-guanidinobenzamides antifertility compounds | NO 2 MILITARY MEDICINE UNIV PL (CN) | 2003-03-12 | — | — | CN | claimed |
| CN-115997016-A | Composition comprising nucleic acid nanoparticles having modular functional groups | 西克斯福德生物科学有限公司 | 2023-04-21 | — | — | CN | disclosed |
| EP-2933265-B1 | Pharmacological chaperones for treating obesity | AMICUS THERAPEUTICS INC (US) | 2018-11-14 | — | — | EP | disclosed |
| EP-1885366-B1 | PHARMACOLOGICAL CHAPERONES FOR TREATING OBESITY | AMICUS THERAPEUTICS INC (US) | 2018-05-30 | — | — | EP | disclosed |
| US-9937165-B2 | Pharmacological chaperones for treating obesity | AMICUS THERAPEUTICS, INC. (US) | 2018-04-10 | — | — | US | disclosed |
| US-9493456-B2 | Pyrazolopyridine and pyrazolopyrimidine derivatives as melanocortin-4 receptor modulators | UNIVERSITE DE MONTREAL (CA) | 2016-11-15 | — | — | US | disclosed |
| US-20160296507-A1 | IMIDAZOPYRIDINE, IMIDAZOPYRIMIDINE AND IMIDAZOPYRAZINE DERIVATIVES AS MELANOCORTIN-4 RECEPTOR MODULATORS | UNIVERSITE DE MONTREAL (CA) | 2016-10-13 | — | — | US | disclosed |
| US-20160287581-A1 | Pharmacological Chaperones for Treating Obesity | WILMINGTON TRUST, NATIONAL ASSOCIATION | 2016-10-06 | — | — | US | disclosed |
| US-9381194-B2 | Pharmacological chaperones for treating obesity | AMICUS THERAPEUTICS, INC. (US) | 2016-07-05 | — | — | US | disclosed |
| WO-2001070204-A2 | HIGHLY SELECTIVE INHIBITORS OF THE UROKINASE PLASMINOGEN ACTIVATOR | WILEX AG (DE) | 2001-09-27 | — | — | WO | disclosed |
| CN-1243505-A | Benzamidine derivatives | AJINOMOTO KK (JP) | 2000-02-02 | — | — | CN | disclosed |
| US-5274162-A | Antineoplastic drugs with bipolar toxification/detoxification functionalities | GLAZIER ARNOLD (US) | 1993-12-28 | — | — | US | disclosed |
| EP-0343894-B1 | BENZAMIDE PROTEASE INHIBITORS | PFIZER INC. (US) | 1992-06-10 | — | — | EP | disclosed |
| US-4948901-A | ANTI-PLASMIN AND ANTI-THROMBIN AGENTS | PFIZER INC. (US) | 1990-08-14 | — | — | US | disclosed |
| US-4948891-A | ANTI-PLASMIN AND ANTI-THROMBIN AGENTS | PFIZER INC. (US) | 1990-08-14 | — | — | US | disclosed |
| EP-0343894-A1 | Benzamide protease inhibitors | PFIZER INC. (US) | 1989-11-29 | — | — | EP | disclosed |
| US-4874864-A | ANTIPLASMIN, ANTITHROMBIN AGENTS | PFIZER INC. (US) | 1989-10-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160296507-A1 | IMIDAZOPYRIDINE, IMIDAZOPYRIMIDINE AND IMIDAZOPYRAZINE DERIVATIVES AS MELANOCORTIN-4 RECEPTOR MODULATORS | MC4R, MC5R, MC1R | KDM4E 2810/4885SMN1; SMN2 3151/4885POLB 4344/4885 |
| US-20160287581-A1 | Pharmacological Chaperones for Treating Obesity | HSPA5, MC4R, HSPA4 | KDM4E 2389/4885SMN1; SMN2 3319/4885POLB 4660/4885 |
| US-20060148901-A1 | Acylated 4-amidino-and-4-guanidinobenzylamines for inhibition of plasma kallikrein | F12, F11, F2 | KDM4E 296/4885SMN1; SMN2 3548/4885POLB 3712/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.