Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEP1A | Q16819 | 1/20 | 0.52 |
| ▸ | MEP1B | Q16820 | 1/20 | 0.52 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.47 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.47 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.47 |
| ▸ | NSD2 | O96028 | 1/20 | 0.46 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.46 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.46 |
| ▸ | AOC3 | Q16853 | 3/20 | 0.45 |
| ▸ | NPC1 | O15118 | 3/20 | 0.44 |
| ▸ | RAB9A | P51151 | 3/20 | 0.44 |
| ▸ | MAOB | P27338 | 1/20 | 0.44 |
| ▸ | GLA | P06280 | 1/20 | 0.43 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.43 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.43 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.43 |
| ▸ | ERCC1 | P07992 | 1/20 | 0.42 |
| ▸ | ERCC4 | Q92889 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29565551 | 0.87 | MEP1A (0.53) | MEP1AMEP1BSLC6A2SLC6A4SLC6A3 | |
| SCHEMBL24160931 | 0.86 | MEP1A (0.56) | MEP1AMEP1BSLC6A2SLC6A4SLC6A3 | |
| SCHEMBL19049388 | 0.86 | MEP1A (0.52) | MEP1AMEP1BSLC6A2SLC6A4SLC6A3 | |
| SCHEMBL19002486 | 0.84 | MEP1A (0.51) | MEP1AMEP1BSLC6A2SLC6A4SLC6A3 | |
| SCHEMBL12505597 | 0.84 | MEP1A (0.56) | MEP1AMEP1BSLC6A2SLC6A4SLC6A3 | |
| SCHEMBL19049392 | 0.83 | SLC6A2 (0.53) | MEP1AMEP1BSLC6A2SLC6A4SLC6A3 | |
| SCHEMBL19002494 | 0.83 | MEP1A (0.53) | MEP1AMEP1BSLC6A2SLC6A4SLC6A3 | |
| SCHEMBL320434 | 0.77 | MEP1A (0.49) | MEP1AMEP1BSLC6A2SLC6A4SLC6A3 | |
| SCHEMBL17882315 | 0.77 | RIPK1 (0.66) | MEP1AMEP1BHSD17B1HSD17B2 | |
| SCHEMBL153971 | 0.76 | MEP1A (0.53) | MEP1AMEP1BSLC6A2SLC6A4SLC6A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-4705630-B2 | — | — | 2011-06-22 | — | — | JP | claimed |
| EP-1732892-A1 | TETRAHYDROCARBAZOLES AND DERIVATIVES | F.HOFFMANN-LA ROCHE AG (CH) | 2006-12-20 | — | — | EP | claimed |
| WO-2005092856-A1 | TETRAHYDROCARBAZOLES AND DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2005-10-06 | — | — | WO | claimed |