Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ECE1 | P42892 | 2/20 | 0.42 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.41 |
| ▸ | KLRK1 | P26718 | 2/20 | 0.40 |
| ▸ | MICA | Q29983 | 2/20 | 0.40 |
| ▸ | RAET1L | Q5VY80 | 2/20 | 0.40 |
| ▸ | MTTP | P55157 | 2/20 | 0.40 |
| ▸ | TMPRSS4 | Q9NRS4 | 2/20 | 0.40 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.39 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.39 |
| ▸ | FPR1 | P21462 | 4/20 | 0.39 |
| ▸ | FPR2 | P25090 | 4/20 | 0.39 |
| ▸ | P2RX1 | P51575 | 1/20 | 0.39 |
| ▸ | P2RX4 | Q99571 | 1/20 | 0.39 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.39 |
| ▸ | KIFC1 | Q9BW19 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | UGCG | Q16739 | 1/20 | 0.39 |
| ▸ | ACLY | P53396 | 1/20 | 0.38 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6530091 | 0.92 | UGCG (0.47) | ECE1PSMB5ITGB1ITGA4CYP3A4 | |
| SCHEMBL13986727 | 0.92 | UGCG (0.47) | ECE1PSMB5ITGB1ITGA4CYP3A4 | |
| SCHEMBL3992055 | 0.88 | P2RX7 (0.42) | ECE1PSMB5ITGB1ITGA4P2RX7 | |
| SCHEMBL3989525 | 0.87 | ITGB1 (0.51) | ECE1PSMB5TMPRSS4ITGB1ITGA4 | |
| SCHEMBL4829787 | 0.87 | ITGB1 (0.51) | ECE1PSMB5TMPRSS4ITGB1ITGA4 | |
| SCHEMBL6097133 | 0.87 | ITGB1 (0.51) | ECE1PSMB5TMPRSS4ITGB1ITGA4 | |
| SCHEMBL3991301 | 0.87 | ITGB1 (0.51) | ECE1PSMB5TMPRSS4ITGB1ITGA4 | |
| SCHEMBL13986728 | 0.87 | PSMB5 (0.46) | ECE1PSMB5TMPRSS4ITGB1ITGA4 | |
| SCHEMBL5544392 | 0.85 | CDK2 (0.47) | ECE1PSMB5TMPRSS4ITGB1ITGA4 | |
| SCHEMBL4827806 | 0.85 | CDK2 (0.47) | ECE1PSMB5TMPRSS4ITGB1ITGA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7544699-B2 | Aryl and heteroaryl compounds, compositions, and methods of use | TRANSTECH PHARMA, INC. (US) | 2009-06-09 | — | — | US | disclosed |
| US-7544699-B2 | Aryl and heteroaryl compounds, compositions, and methods of use | TRANSTECH PHARMA, INC. (US) | 2009-06-09 | — | — | US | disclosed |