Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.61 |
| ▸ | PKM | P14618 | 2/20 | 0.61 |
| ▸ | RAB9A | P51151 | 2/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.61 |
| ▸ | LMNA | P02545 | 1/20 | 0.61 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | KDM1A | O60341 | 1/20 | 0.44 |
| ▸ | IMPDH2 | P12268 | 5/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13796619 | 0.83 | CTNNB1 (0.52) | NPC1KDM4ERAB9AALDH1A1LMNA | |
| SCHEMBL13797656 | 0.81 | ADORA3 (0.54) | NPC1KDM4ERAB9AALDH1A1LMNA | |
| SCHEMBL13797660 | 0.80 | ADRA2A (0.47) | KDM4EALDH1A1KDM1AMAPTRXFP1 | |
| SCHEMBL13794681 | 0.80 | MCHR1 (0.70) | ADRA2AMCHR1 | |
| SCHEMBL13797641 | 0.80 | MEN1 (0.50) | NPC1KDM4ERAB9AALDH1A1LMNA | |
| SCHEMBL13797655 | 0.78 | PLAU (0.57) | NPC1KDM4EALDH1A1LMNAHTT | |
| SCHEMBL13797659 | 0.77 | MEN1 (0.62) | PKMALDH1A1LMNAMAPTMEN1 | |
| SCHEMBL13797645 | 0.77 | KDM4E (0.51) | NPC1KDM4EPKMRAB9AALDH1A1 | |
| SCHEMBL13793902 | 0.76 | MCHR1 (0.56) | ADRA2AMCHR1 | |
| SCHEMBL13797650 | 0.76 | MAPT (0.51) | NPC1RAB9AMAPTRXFP1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7544690-B2 | MCH receptor antagonists | TAISHO PHARMACEUTICAL CO., LTD. (JP) | 2009-06-09 | — | — | US | disclosed |
| US-7544690-B2 | MCH receptor antagonists | TAISHO PHARMACEUTICAL CO., LTD. (JP) | 2009-06-09 | — | — | US | disclosed |