Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2A | P08913 | 4/20 | 0.47 |
| ▸ | MCHR1 | Q99705 | 4/20 | 0.47 |
| ▸ | CTNNB1 | P35222 | 2/20 | 0.46 |
| ▸ | TCF7L2 | Q9NQB0 | 2/20 | 0.46 |
| ▸ | KDM1A | O60341 | 2/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | HTR1A | P08908 | 1/20 | 0.44 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.44 |
| ▸ | HRH1 | P35367 | 1/20 | 0.44 |
| ▸ | HTR2B | P41595 | 1/20 | 0.44 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13796619 | 0.93 | CTNNB1 (0.52) | ADRA2AMCHR1CTNNB1TCF7L2KDM1A | |
| SCHEMBL13797656 | 0.85 | ADORA3 (0.54) | ADRA2AMCHR1KDM1ACYP3A4MEN1 | |
| SCHEMBL13797655 | 0.83 | PLAU (0.57) | ADRA2AMCHR1CYP3A4MEN1KMT2A | |
| SCHEMBL13797641 | 0.82 | MEN1 (0.50) | ADRA2AMCHR1CTNNB1TCF7L2KDM1A | |
| SCHEMBL13797644 | 0.80 | NPC1 (0.61) | ADRA2AMCHR1CTNNB1TCF7L2KDM1A | |
| SCHEMBL13797650 | 0.80 | MAPT (0.51) | MEN1KMT2ATP53MAPTRXFP1 | |
| SCHEMBL13796634 | 0.79 | CTNNB1 (0.69) | CTNNB1TCF7L2 | |
| SCHEMBL13797640 | 0.77 | ADRA2A (0.45) | ADRA2AMCHR1CTNNB1TCF7L2KDM1A | |
| SCHEMBL13797649 | 0.77 | MAPT (0.56) | CTNNB1TCF7L2CYP3A4MEN1KMT2A | |
| SCHEMBL13797210 | 0.77 | CTNNB1 (0.63) | CTNNB1TCF7L2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7544690-B2 | MCH receptor antagonists | TAISHO PHARMACEUTICAL CO., LTD. (JP) | 2009-06-09 | — | — | US | disclosed |
| US-7544690-B2 | MCH receptor antagonists | TAISHO PHARMACEUTICAL CO., LTD. (JP) | 2009-06-09 | — | — | US | disclosed |