Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 3/20 | 0.49 |
| ▸ | LYN | P07948 | 1/20 | 0.45 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 3/20 | 0.40 |
| ▸ | RAB9A | P51151 | 3/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 3/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | GLA | P06280 | 1/20 | 0.38 |
| ▸ | CASP3 | P42574 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.38 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.38 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13797936 | 0.86 | MAPK14 (0.68) | MAPK14LYNMAPK9NPC1RAB9A | |
| SCHEMBL13359141 | 0.85 | LYN (0.45) | MAPK14LYNMAPK9NPC1RAB9A | |
| SCHEMBL13359211 | 0.84 | MAPK14 (0.40) | MAPK14LYNMAPK9NPC1RAB9A | |
| SCHEMBL13359241 | 0.81 | LYN (0.55) | MAPK14LYNMAPK9MEN1KMT2A | |
| SCHEMBL13359212 | 0.80 | LYN (0.51) | MAPK14LYNMAPK9NPC1RAB9A | |
| SCHEMBL13359264 | 0.79 | LYN (0.59) | MAPK14LYNMAPK9NPC1RAB9A | |
| SCHEMBL13359291 | 0.78 | SMN1; SMN2 (0.51) | NPC1RAB9AMAPK1SMN1; SMN2GAA | |
| SCHEMBL13359215 | 0.76 | MAPK14 (0.52) | MAPK14NPC1RAB9AGAAMEN1 | |
| SCHEMBL13359267 | 0.75 | NPC1 (0.49) | NPC1RAB9AMAPK1SMN1; SMN2GAA | |
| SCHEMBL13359156 | 0.74 | MAPK14 (0.44) | MAPK14LYNMAPK9RAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1497278-B1 | HETEROCYCLIC AMIDE DERIVATIVES AS CYTOKINE INHIBITORS | BOEHRINGER INGELHEIM PHARMA (US) | 2010-05-26 | — | — | EP | disclosed |