Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 3/20 | 0.47 |
| ▸ | ACACB | O00763 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.44 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | ESR1 | P03372 | 2/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.43 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.43 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | PDE4A | P27815 | 1/20 | 0.43 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.43 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11577701 | 0.83 | TDP1 (0.56) | TAAR1LMNAMAPTALDH1A1GAA | |
| SCHEMBL5732933 | 0.82 | LMNA (0.46) | LMNAMAPTALDH1A1GAAHSP90AA1 | |
| SCHEMBL111718 | 0.81 | TSHR (0.60) | LMNAMAPTALDH1A1GAAHSP90AA1 | |
| Hydrochloric Acid SCHEMBL2457796 | 0.81 | LMNA (0.44) | LMNAMAPTALDH1A1GAAHSP90AA1 | |
| Hydrochloric Acid SCHEMBL2528523 | 0.80 | LMNA (0.43) | LMNAMAPTALDH1A1GAAHSP90AA1 | |
| SCHEMBL11234964 | 0.79 | LMNA (0.50) | LMNAMAPTALDH1A1GAAHSP90AA1 | |
| SCHEMBL24171452 | 0.78 | LMNA (0.48) | LMNAMAPTALDH1A1GAAHSP90AA1 | |
| SCHEMBL8476326 | 0.78 | FFAR1 (0.53) | LMNAMAPTALDH1A1GAAHSP90AA1 | |
| SCHEMBL19968620 | 0.78 | ESR1 (0.55) | LMNAMAPTALDH1A1TSHRKDM4E | |
| SCHEMBL13784555 | 0.78 | LMNA (0.48) | LMNAACACBMAPTALDH1A1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170216249-A1 | Substituted Phenyl Aziridine Precursor Analogs for Inhibiting Androgen-Independent Prostate Cancer Cell Growth | NORTHWESTERN UNIVERSITY (US) | 2017-08-03 | — | — | US | disclosed |
| US-20160089354-A1 | Substituted Phenyl Aziridine Precursor Analogs for Inhibiting Androgen-Independent Cancer Cell Growth | NORTHWESTERN UNIVERSITY (US) | 2016-03-31 | — | — | US | disclosed |
| US-20140045938-A1 | Substituted Phenyl Aziridine Precursor Analogs for Inhibiting Androgen-Independent Prostate Cancer Cell Growth | NORTHWESTERN UNIVERSITY (US) | 2014-02-13 | — | — | US | disclosed |
| US-20090156672-A1 | Substituted Phenyl Aziridine Precursor Analogs as Modulators of Steroid Receptor Activities | NORTHWESTERN UNIVERSITY (US) | 2009-06-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160089354-A1 | Substituted Phenyl Aziridine Precursor Analogs for Inhibiting Androgen-Independent Cancer Cell Growth | NR5A1, AR, CYP17A1 | TAAR1 2173/4885LMNA 4562/4885ACACB 2210/4885 |
| US-20170216249-A1 | Substituted Phenyl Aziridine Precursor Analogs for Inhibiting Androgen-Independent Prostate Cancer Cell Growth | NR5A1, AR, CYP17A1 | TAAR1 2603/4885LMNA 4589/4885ACACB 2227/4885 |
| US-20140045938-A1 | Substituted Phenyl Aziridine Precursor Analogs for Inhibiting Androgen-Independent Prostate Cancer Cell Growth | NR5A1, AR, CYP17A1 | TAAR1 2603/4885LMNA 4589/4885ACACB 2227/4885 |
| US-20090156672-A1 | Substituted Phenyl Aziridine Precursor Analogs as Modulators of Steroid Receptor Activities | NR5A1, AR, NR3C1 | TAAR1 1689/4885LMNA 4632/4885ACACB 2833/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.