Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 1/20 | 0.41 |
| ▸ | DRD2 | P14416 | 2/20 | 0.38 |
| ▸ | DRD3 | P35462 | 2/20 | 0.38 |
| ▸ | LTA4H | P09960 | 2/20 | 0.37 |
| ▸ | PEPD | P12955 | 1/20 | 0.37 |
| ▸ | XPNPEP1 | Q9NQW7 | 1/20 | 0.37 |
| ▸ | PTGDR | Q13258 | 1/20 | 0.37 |
| ▸ | HTR2A | P28223 | 1/20 | 0.36 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.35 |
| ▸ | DRD1 | P21728 | 1/20 | 0.35 |
| ▸ | DRD4 | P21917 | 1/20 | 0.35 |
| ▸ | DRD5 | P21918 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15998448 | 1.00 | HSD11B1 (0.41) | HSD11B1DRD2DRD3LTA4HPEPD | |
| SCHEMBL13804311 | 1.00 | HSD11B1 (0.41) | HSD11B1DRD2DRD3LTA4HPEPD | |
| SCHEMBL13804315 | 0.90 | LTA4H (0.43) | HSD11B1DRD2LTA4HPEPDXPNPEP1 | |
| SCHEMBL13804280 | 0.90 | LTA4H (0.43) | HSD11B1DRD2LTA4HPEPDXPNPEP1 | |
| SCHEMBL9911081 | 0.81 | HSD11B1 (0.43) | HSD11B1DRD2DRD3LTA4HPEPD | |
| SCHEMBL12259816 | 0.81 | HSD11B1 (0.43) | HSD11B1DRD2DRD3LTA4HPEPD | |
| SCHEMBL12258693 | 0.77 | HSD11B1 (0.41) | HSD11B1DRD2DRD3PEPDXPNPEP1 | |
| SCHEMBL12259103 | 0.77 | HSD11B1 (0.41) | HSD11B1DRD2DRD3PEPDXPNPEP1 | |
| SCHEMBL13804294 | 0.73 | LTA4H (0.40) | HSD11B1LTA4HPEPDXPNPEP1PTGDR | |
| SCHEMBL13783347 | 0.72 | GRIK1 (0.40) | HSD11B1LTA4H |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2225238-B1 | DERIVATIVES OF 6,7-DIHYDRO-5H-IMIDAZOÝ1,2- ¨IMIDAZOLE-3- CARBOXYLIC ACID AMIDES | BOEHRINGER INGELHEIM INT (DE) | 2014-09-03 | — | — | EP | disclosed |
| WO-2009070485-A1 | DERIVATIVES OF 6,7-DIHYDRO-5H-IMIDAZO[1,2-α]IMIDAZOLE-3- CARBOXYLIC ACID AMIDES | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2009-06-04 | — | — | WO | disclosed |