Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 2/20 | 0.43 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.36 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.33 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.33 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.33 |
| ▸ | GRIA3 | P42263 | 1/20 | 0.33 |
| ▸ | GRIA4 | P48058 | 1/20 | 0.33 |
| ▸ | GRIK2 | Q13002 | 1/20 | 0.33 |
| ▸ | GRIK3 | Q13003 | 1/20 | 0.33 |
| ▸ | GRIK4 | Q16099 | 1/20 | 0.33 |
| ▸ | GRIK5 | Q16478 | 1/20 | 0.33 |
| ▸ | PEPD | P12955 | 1/20 | 0.33 |
| ▸ | XPNPEP1 | Q9NQW7 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | PTGDR | Q13258 | 1/20 | 0.32 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.32 |
| ▸ | DRD2 | P14416 | 1/20 | 0.31 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.31 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13804280 | 1.00 | LTA4H (0.43) | LTA4HHSD11B1GRIK1GRIA1GRIA2 | |
| SCHEMBL13804311 | 0.90 | HSD11B1 (0.41) | LTA4HHSD11B1PEPDXPNPEP1PTGDR | |
| SCHEMBL13804284 | 0.90 | HSD11B1 (0.41) | LTA4HHSD11B1PEPDXPNPEP1PTGDR | |
| SCHEMBL15998448 | 0.90 | HSD11B1 (0.41) | LTA4HHSD11B1PEPDXPNPEP1PTGDR | |
| SCHEMBL13804294 | 0.79 | LTA4H (0.40) | LTA4HHSD11B1GRIK1GRIA1GRIA2 | |
| SCHEMBL12258702 | 0.75 | KDM5A (0.36) | LTA4HHSD11B1GRIK1GRIA1GRIA2 | |
| SCHEMBL12258733 | 0.75 | KDM5A (0.36) | LTA4HHSD11B1GRIK1GRIA1GRIA2 | |
| SCHEMBL13783323 | 0.75 | LTA4H (0.44) | LTA4HHSD11B1GRIK1GRIA1GRIA2 | |
| SCHEMBL13938027 | 0.74 | S1PR1 (0.54) | LTA4HHRH3 | |
| SCHEMBL9911081 | 0.73 | HSD11B1 (0.43) | LTA4HHSD11B1GRIK1GRIA1GRIA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2225238-B1 | DERIVATIVES OF 6,7-DIHYDRO-5H-IMIDAZOÝ1,2- ¨IMIDAZOLE-3- CARBOXYLIC ACID AMIDES | BOEHRINGER INGELHEIM INT (DE) | 2014-09-03 | — | — | EP | disclosed |
| WO-2009070485-A1 | DERIVATIVES OF 6,7-DIHYDRO-5H-IMIDAZO[1,2-α]IMIDAZOLE-3- CARBOXYLIC ACID AMIDES | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2009-06-04 | — | — | WO | disclosed |