Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 12/20 | 0.52 |
| ▸ | TP53 | P04637 | 3/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.52 |
| ▸ | RAB9A | P51151 | 7/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.39 |
| ▸ | HTT | P42858 | 6/20 | 0.39 |
| ▸ | NPC1 | O15118 | 6/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.38 |
| ▸ | LMNA | P02545 | 4/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | EGFR | P00533 | 1/20 | 0.36 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19879909 | 0.87 | ALDH1A1 (0.48) | ALDH1A1TP53RAB9AKMT2AHTT | |
| SCHEMBL6247670 | 0.79 | ALDH1A1 (0.42) | ALDH1A1TP53RAB9AKMT2AHTT | |
| SCHEMBL11635095 | 0.79 | RAB9A (0.46) | ALDH1A1TP53TSHRRAB9AKMT2A | |
| SCHEMBL5351542 | 0.79 | ALDH1A1 (0.58) | ALDH1A1HSD17B10RAB9AKMT2AHTT | |
| SCHEMBL21986138 | 0.79 | ALDH1A1 (0.48) | ALDH1A1TP53MAPK1HSD17B10TSHR | |
| SCHEMBL4487778 | 0.78 | HIF1A (0.42) | ALDH1A1TP53HIF1ARAB9AKMT2A | |
| SCHEMBL22311426 | 0.78 | POLQ (0.48) | ALDH1A1HSD17B10RAB9AKMT2AHTT | |
| SCHEMBL3588249 | 0.78 | PPIB (0.46) | ALDH1A1TP53MAPK1TSHRRAB9A | |
| SCHEMBL1507876 | 0.77 | ALDH1A1 (0.64) | ALDH1A1TP53RAB9AKMT2AHTT | |
| SCHEMBL9322458 | 0.76 | EGFR (0.43) | ALDH1A1TP53RAB9AKMT2AHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2229359-B1 | PROCESS FOR THE MANUFACTURE OF AN INDOLINONE DERIVATIVE | BOEHRINGER INGELHEIM INT (DE) | 2017-11-29 | — | — | EP | disclosed |
| WO-2009071523-A1 | PROCESS FOR THE MANUFACTURE OF AN INDOLINONE DERIVATIVE | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2009-06-11 | — | — | WO | disclosed |