Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYRO3 | Q06418 | 1/20 | 0.36 |
| ▸ | NOS3 | P29474 | 6/20 | 0.35 |
| ▸ | NOS2 | P35228 | 6/20 | 0.35 |
| ▸ | NOS1 | P29475 | 3/20 | 0.33 |
| ▸ | F12 | P00748 | 1/20 | 0.33 |
| ▸ | PLAU | P00749 | 1/20 | 0.33 |
| ▸ | NCF1 | P14598 | 1/20 | 0.33 |
| ▸ | BACE1 | P56817 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14621102 | 0.77 | NOS2 (0.54) | TYRO3NOS3NOS2NOS1F12 | |
| SCHEMBL19489657 | 0.77 | KDM4E (0.39) | TYRO3NOS3NOS2NOS1F12 | |
| SCHEMBL20170312 | 0.72 | NOS2 (0.43) | TYRO3NOS3NOS2NOS1 | |
| SCHEMBL25781462 | 0.72 | TYRO3 (0.33) | TYRO3NOS3NOS2 | |
| SCHEMBL22621035 | 0.70 | TYRO3 (0.32) | TYRO3NOS3NOS2NOS1F12 | |
| SCHEMBL12891981 | 0.69 | PI4KA (0.34) | TYRO3 | |
| SCHEMBL8223090 | 0.68 | — | — | |
| SCHEMBL30082398 | 0.68 | — | — | |
| SCHEMBL22493687 | 0.68 | — | — | |
| SCHEMBL10064848 | 0.68 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009073300-A1 | [1H- PYRAZOLO [3, 4-B] PYRIDINE-4-YL] -PHENYLE OR -PYRIDIN-2-YLE DERIVATIVES AS PROTEIN KINASE C-THETA | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2009-06-11 | — | — | WO | disclosed |