Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PCSK9 | Q8NBP7 | 1/20 | 0.65 |
| ▸ | MAOA | P21397 | 3/20 | 0.60 |
| ▸ | MAOB | P27338 | 3/20 | 0.60 |
| ▸ | TSHR | P16473 | 6/20 | 0.59 |
| ▸ | HTT | P42858 | 4/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.57 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.57 |
| ▸ | TP53 | P04637 | 2/20 | 0.57 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.57 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.56 |
| ▸ | GPR18 | Q14330 | 1/20 | 0.54 |
| ▸ | LMNA | P02545 | 2/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 2/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.53 |
| ▸ | GFER | P55789 | 1/20 | 0.53 |
| ▸ | HPGD | P15428 | 1/20 | 0.52 |
| ▸ | ATM | Q13315 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16029603 | 0.87 | MAOA (0.59) | PCSK9MAOAMAOBTSHRHTT | |
| SCHEMBL13809153 | 0.86 | TP53 (0.69) | PCSK9TSHRHTTALDH1A1ALOX15 | |
| SCHEMBL16079548 | 0.86 | MAOA (0.58) | PCSK9MAOAMAOBTSHRHTT | |
| SCHEMBL556399 | 0.85 | SMN1; SMN2 (0.69) | PCSK9MAOAMAOBTSHRHTT | |
| SCHEMBL19560336 | 0.85 | PCSK9 (0.54) | PCSK9MAOAMAOBTSHRHTT | |
| SCHEMBL8298465 | 0.81 | ALDH1A1 (0.66) | PCSK9MAOAMAOBTSHRHTT | |
| SCHEMBL17791619 | 0.81 | ALDH1A1 (0.84) | TSHRHTTALDH1A1ALOX15TP53 | |
| SCHEMBL17791628 | 0.80 | ALDH1A1 (0.65) | PCSK9TSHRHTTALDH1A1ALOX15 | |
| SCHEMBL17791630 | 0.79 | ALDH1A1 (0.64) | TSHRHTTALDH1A1ALOX15TP53 | |
| SCHEMBL12604428 | 0.79 | DPP4 (0.77) | PCSK9MAOAMAOBTSHRHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1319003-B1 | XANTHINE PHOSPHODIESTERASE V INHIBITORS | SCHERING CORP (US) | 2009-06-10 | — | — | EP | disclosed |