Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 2/20 | 0.69 |
| ▸ | TSHR | P16473 | 5/20 | 0.69 |
| ▸ | HTT | P42858 | 6/20 | 0.68 |
| ▸ | LMNA | P02545 | 2/20 | 0.67 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.67 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.65 |
| ▸ | GFER | P55789 | 1/20 | 0.65 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.64 |
| ▸ | CASP1 | P29466 | 1/20 | 0.64 |
| ▸ | CASP7 | P55210 | 1/20 | 0.64 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.63 |
| ▸ | USP2 | O75604 | 1/20 | 0.63 |
| ▸ | MAPT | P10636 | 4/20 | 0.62 |
| ▸ | PCSK9 | Q8NBP7 | 1/20 | 0.62 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.56 |
| ▸ | POLB | P06746 | 1/20 | 0.56 |
| ▸ | HPGD | P15428 | 1/20 | 0.56 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13809397 | 0.86 | PCSK9 (0.65) | TP53TSHRHTTLMNASMN1; SMN2 | |
| SCHEMBL16029366 | 0.85 | HTT (0.61) | TP53TSHRHTTLMNASMN1; SMN2 | |
| SCHEMBL555962 | 0.85 | HTT (0.74) | TP53TSHRHTTLMNASMN1; SMN2 | |
| SCHEMBL16079532 | 0.84 | HTT (0.60) | TP53TSHRHTTLMNASMN1; SMN2 | |
| SCHEMBL7016485 | 0.82 | ALDH1A1 (0.60) | TP53TSHRHTTLMNASMN1; SMN2 | |
| SCHEMBL17791591 | 0.79 | HSD17B10 (1.00) | TP53TSHRHTTLMNASMN1; SMN2 | |
| SCHEMBL13939505 | 0.79 | NPSR1 (0.76) | TP53TSHRHTTLMNASMN1; SMN2 | |
| SCHEMBL13938418 | 0.78 | NPSR1 (0.65) | TP53TSHRHTTLMNASMN1; SMN2 | |
| SCHEMBL24769080 | 0.77 | PCSK9 (1.00) | TP53TSHRHTTLMNASMN1; SMN2 | |
| SCHEMBL555168 | 0.77 | DPP4 (0.80) | TP53TSHRHTTLMNASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1319003-B1 | XANTHINE PHOSPHODIESTERASE V INHIBITORS | SCHERING CORP (US) | 2009-06-10 | — | — | EP | disclosed |