Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.57 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.40 |
| ▸ | JAK2 | O60674 | 1/20 | 0.38 |
| ▸ | JAK1 | P23458 | 1/20 | 0.38 |
| ▸ | SCD5 | Q86SK9 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1639199 | 0.88 | GPR119 (0.57) | GPR119ALOX15TP53MAPTHSD17B10 | |
| SCHEMBL2401311 | 0.86 | GPR119 (0.52) | GPR119ALOX15TP53MAPTHSD17B10 | |
| SCHEMBL31470380 | 0.84 | GPR119 (0.53) | GPR119ALOX15TP53MAPTHSD17B10 | |
| SCHEMBL31470348 | 0.83 | GPR119 (0.48) | GPR119ALOX15TP53MAPTHSD17B10 | |
| SCHEMBL13170189 | 0.81 | GPR119 (0.50) | GPR119USP2SMN1; SMN2SCD5 | |
| SCHEMBL23097412 | 0.81 | MAPT (0.40) | GPR119MAPTHSD17B10 | |
| SCHEMBL12901469 | 0.80 | GPR119 (0.49) | GPR119PKMUSP2SMN1; SMN2 | |
| SCHEMBL12901537 | 0.80 | GPR119 (0.49) | GPR119USP2SMN1; SMN2 | |
| SCHEMBL31470342 | 0.80 | GPR119 (0.50) | GPR119PKMALOX15TP53MAPT | |
| SCHEMBL2599806 | 0.79 | PKM (0.55) | GPR119PKMJAK2JAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1954698-B1 | SPIROCYCLIC COMPOUNDS AS HDAC INHIBITORS | MERCK & CO INC (US) | 2009-06-24 | — | — | EP | disclosed |