Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT2 | Q8IXJ6 | 11/20 | 0.59 |
| ▸ | MEN1 | O00255 | 2/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.55 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.53 |
| ▸ | NPC1 | O15118 | 2/20 | 0.49 |
| ▸ | RAB9A | P51151 | 2/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13812549 | 0.86 | SIRT2 (0.58) | SIRT2NR1H4 | |
| SCHEMBL13812777 | 0.86 | SIRT2 (0.59) | SIRT2MEN1KMT2ANR1H4 | |
| SCHEMBL13812551 | 0.85 | SIRT2 (0.52) | SIRT2MEN1KMT2ANR1H4NPC1 | |
| SCHEMBL13812545 | 0.85 | MEN1 (0.55) | SIRT2MEN1KMT2ANR1H4NPC1 | |
| SCHEMBL13812547 | 0.85 | MEN1 (0.55) | SIRT2MEN1KMT2ANR1H4NPC1 | |
| SCHEMBL13812736 | 0.85 | KCNK3 (0.56) | SIRT2MEN1KMT2ANR1H4NPC1 | |
| SCHEMBL13812584 | 0.85 | MEN1 (0.53) | SIRT2MEN1KMT2ANR1H4NPC1 | |
| SCHEMBL13812550 | 0.85 | SIRT2 (0.52) | SIRT2MEN1KMT2ANR1H4NPC1 | |
| SCHEMBL13812761 | 0.84 | SIRT2 (0.60) | SIRT2MEN1KMT2ANR1H4NPC1 | |
| SCHEMBL13812767 | 0.83 | KCNK3 (0.54) | SIRT2MEN1KMT2ANR1H4RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7547804-B2 | Compounds, compositions, and methods employing same | MYRIAD GENETICS, INC. (US) | 2009-06-16 | — | — | US | disclosed |
| US-7547804-B2 | Compounds, compositions, and methods employing same | MYRIAD GENETICS, INC. (US) | 2009-06-16 | — | — | US | disclosed |