Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNK3 | O14649 | 4/20 | 0.56 |
| ▸ | KCNK9 | Q9NPC2 | 4/20 | 0.56 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.56 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.55 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.55 |
| ▸ | RAB9A | P51151 | 4/20 | 0.54 |
| ▸ | NPC1 | O15118 | 3/20 | 0.54 |
| ▸ | TP53 | P04637 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.54 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.53 |
| ▸ | POLB | P06746 | 2/20 | 0.53 |
| ▸ | MET | P08581 | 1/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.52 |
| ▸ | GAA | P10253 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13812742 | 0.89 | KCNK3 (0.56) | KCNK3KCNK9KLKB1SIRT2RAB9A | |
| SCHEMBL13812777 | 0.88 | SIRT2 (0.59) | KCNK3KCNK9SIRT2NR1H4POLB | |
| SCHEMBL13812761 | 0.86 | SIRT2 (0.60) | SIRT2NR1H4RAB9ANPC1TP53 | |
| SCHEMBL13812764 | 0.85 | LRRK2 (0.55) | KCNK3KCNK9SIRT2NR1H4LRRK2 | |
| SCHEMBL13812751 | 0.85 | FADS1 (0.60) | SIRT2NR1H4RAB9ANPC1LRRK2 | |
| SCHEMBL13812546 | 0.85 | SIRT2 (0.59) | SIRT2NR1H4RAB9ANPC1SMN1; SMN2 | |
| SCHEMBL13812749 | 0.85 | MET (0.60) | KLKB1SIRT2NR1H4RAB9ANPC1 | |
| SCHEMBL13812767 | 0.85 | KCNK3 (0.54) | KCNK3KCNK9SIRT2NR1H4RAB9A | |
| SCHEMBL13812789 | 0.84 | NR1H4 (0.61) | SIRT2NR1H4KDM4EMAPK1GAA | |
| SCHEMBL13812549 | 0.82 | SIRT2 (0.58) | SIRT2NR1H4GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7547804-B2 | Compounds, compositions, and methods employing same | MYRIAD GENETICS, INC. (US) | 2009-06-16 | — | — | US | disclosed |
| US-7547804-B2 | Compounds, compositions, and methods employing same | MYRIAD GENETICS, INC. (US) | 2009-06-16 | — | — | US | disclosed |