Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT2 | Q8IXJ6 | 4/20 | 0.60 |
| ▸ | NR1H4 | Q96RI1 | 2/20 | 0.59 |
| ▸ | LMNA | P02545 | 2/20 | 0.55 |
| ▸ | MEN1 | O00255 | 2/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.55 |
| ▸ | TP53 | P04637 | 1/20 | 0.55 |
| ▸ | HPGD | P15428 | 1/20 | 0.55 |
| ▸ | HTT | P42858 | 1/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.55 |
| ▸ | ALOX15 | P16050 | 4/20 | 0.54 |
| ▸ | PNLIP | P16233 | 2/20 | 0.53 |
| ▸ | P2RX1 | P51575 | 2/20 | 0.53 |
| ▸ | FADS1 | O60427 | 1/20 | 0.53 |
| ▸ | TERT | O14746 | 1/20 | 0.51 |
| ▸ | NPC1 | O15118 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13812748 | 0.89 | NR1H4 (0.55) | SIRT2NR1H4LMNAMEN1KMT2A | |
| SCHEMBL13812756 | 0.89 | NR1H4 (0.55) | SIRT2NR1H4LMNAMEN1KMT2A | |
| SCHEMBL13812778 | 0.88 | NR1H4 (0.54) | SIRT2NR1H4LMNAMEN1KMT2A | |
| SCHEMBL3863657 | 0.88 | P2RX1 (0.62) | SIRT2NR1H4MEN1KMT2AP2RX1 | |
| SCHEMBL13812759 | 0.88 | LRRK2 (0.58) | SIRT2NR1H4ALOX15P2RX1FADS1 | |
| SCHEMBL13812782 | 0.88 | NR1H4 (0.54) | SIRT2NR1H4LMNAMEN1KMT2A | |
| SCHEMBL13812777 | 0.87 | SIRT2 (0.59) | SIRT2NR1H4LMNAMEN1KMT2A | |
| SCHEMBL13812751 | 0.87 | FADS1 (0.60) | SIRT2NR1H4MEN1KMT2AKDM4E | |
| SCHEMBL13812749 | 0.87 | MET (0.60) | SIRT2NR1H4MEN1KMT2AKDM4E | |
| SCHEMBL13812545 | 0.87 | MEN1 (0.55) | SIRT2NR1H4LMNAMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7547804-B2 | Compounds, compositions, and methods employing same | MYRIAD GENETICS, INC. (US) | 2009-06-16 | — | — | US | disclosed |
| US-7547804-B2 | Compounds, compositions, and methods employing same | MYRIAD GENETICS, INC. (US) | 2009-06-16 | — | — | US | disclosed |