Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.55 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.52 |
| ▸ | NPC1 | O15118 | 2/20 | 0.52 |
| ▸ | RAB9A | P51151 | 2/20 | 0.52 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 3/20 | 0.49 |
| ▸ | FADS1 | O60427 | 1/20 | 0.49 |
| ▸ | AHR | P35869 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13812545 | 0.92 | MEN1 (0.55) | MEN1KMT2ANR1H4SMN1; SMN2NPC1 | |
| SCHEMBL13812778 | 0.88 | NR1H4 (0.54) | MEN1KMT2ANR1H4RAB9ASIRT2 | |
| SCHEMBL13812751 | 0.87 | FADS1 (0.60) | MEN1KMT2ANR1H4NPC1RAB9A | |
| SCHEMBL13812748 | 0.87 | NR1H4 (0.55) | MEN1KMT2ANR1H4SMN1; SMN2SIRT2 | |
| SCHEMBL13812761 | 0.87 | SIRT2 (0.60) | MEN1KMT2ANR1H4NPC1RAB9A | |
| SCHEMBL13812759 | 0.86 | LRRK2 (0.58) | NR1H4SIRT2FADS1 | |
| SCHEMBL3863657 | 0.86 | P2RX1 (0.62) | MEN1KMT2ANR1H4NPC1RAB9A | |
| SCHEMBL13812546 | 0.85 | SIRT2 (0.59) | MEN1KMT2ANR1H4SMN1; SMN2NPC1 | |
| SCHEMBL13812782 | 0.82 | NR1H4 (0.54) | MEN1KMT2ANR1H4SIRT2LMNA | |
| SCHEMBL13812777 | 0.81 | SIRT2 (0.59) | MEN1KMT2ANR1H4SIRT2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7547804-B2 | Compounds, compositions, and methods employing same | MYRIAD GENETICS, INC. (US) | 2009-06-16 | — | — | US | disclosed |
| US-7547804-B2 | Compounds, compositions, and methods employing same | MYRIAD GENETICS, INC. (US) | 2009-06-16 | — | — | US | disclosed |