Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 8/20 | 0.76 |
| ▸ | EP300 | Q09472 | 4/20 | 0.65 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.65 |
| ▸ | LMNA | P02545 | 2/20 | 0.65 |
| ▸ | BCHE | P06276 | 2/20 | 0.65 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.65 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.65 |
| ▸ | MAPT | P10636 | 2/20 | 0.65 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.65 |
| ▸ | DRD2 | P14416 | 2/20 | 0.65 |
| ▸ | TSHR | P16473 | 2/20 | 0.65 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.65 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.65 |
| ▸ | RXRA | P19793 | 2/20 | 0.65 |
| ▸ | DRD1 | P21728 | 2/20 | 0.65 |
| ▸ | ACHE | P22303 | 2/20 | 0.65 |
| ▸ | HTR2B | P41595 | 2/20 | 0.65 |
| ▸ | HTT | P42858 | 2/20 | 0.65 |
| ▸ | RAD52 | P43351 | 2/20 | 0.65 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.65 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13814556 | 0.90 | P2RX7 (0.81) | P2RX7EP300ALDH1A1LMNABCHE | |
| SCHEMBL299398 | 0.88 | P2RX7 (0.78) | P2RX7EP300ALDH1A1LMNABCHE | |
| SCHEMBL31214707 | 0.88 | P2RX7 (0.78) | P2RX7EP300ALDH1A1LMNABCHE | |
| SCHEMBL298305 | 0.87 | P2RX7 (1.00) | P2RX7EP300ALDH1A1LMNABCHE | |
| SCHEMBL13814557 | 0.85 | P2RX7 (0.70) | P2RX7EP300ALDH1A1LMNABCHE | |
| SCHEMBL14513612 | 0.85 | P2RX7 (0.89) | P2RX7EP300ALDH1A1LMNABCHE | |
| SCHEMBL14513594 | 0.85 | P2RX7 (0.79) | P2RX7EP300ALDH1A1LMNABCHE | |
| SCHEMBL14513599 | 0.83 | P2RX7 (0.62) | P2RX7EP300ALDH1A1LMNABCHE | |
| SCHEMBL13814544 | 0.82 | P2RX7 (0.81) | P2RX7EP300ALDH1A1LMNABCHE | |
| SCHEMBL14513605 | 0.82 | P2RX7 (0.84) | P2RX7EP300ALDH1A1LMNABCHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2070926-A1 | 13,13a-DIHYDROBERBERINE DERIVATIVES, THEIR PHARMACEUTICAL COMPOSITION AND USE | Shanghai Institute of Materia Medica, Chinese Academy of Sciences (CN) | 2009-06-17 | — | — | EP | disclosed |
| US-20070098649-A1 | Method and composition for controlling oral pathogens | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (IL) | 2007-05-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070098649-A1 | Method and composition for controlling oral pathogens | BROX, NOP2, FBL | P2RX7 2447/4885EP300 3990/4885ALDH1A1 4776/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.