Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H4 | Q96RI1 | 2/20 | 0.50 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.47 |
| ▸ | CASR | P41180 | 3/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | ATM | Q13315 | 1/20 | 0.46 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.46 |
| ▸ | ACP3 | P15309 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.41 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.41 |
| ▸ | CNR1 | P21554 | 1/20 | 0.41 |
| ▸ | HRH1 | P35367 | 1/20 | 0.41 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.41 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | GHSR | Q92847 | 1/20 | 0.41 |
| ▸ | PDE2A | O00408 | 1/20 | 0.41 |
| ▸ | GRIA4 | P48058 | 2/20 | 0.41 |
| ▸ | MAOA | P21397 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13439868 | 1.00 | NR1H4 (0.50) | NR1H4SIGMAR1CASRGAATDP1 | |
| SCHEMBL3749295 | 0.82 | SIGMAR1 (0.61) | SIGMAR1CASRGAAATMACP3 | |
| SCHEMBL30763462 | 0.82 | SIGMAR1 (0.61) | SIGMAR1CASRGAAATMACP3 | |
| SCHEMBL1200137 | 0.82 | SIGMAR1 (0.61) | SIGMAR1CASRGAAATMACP3 | |
| SCHEMBL283979 | 0.82 | SIGMAR1 (0.61) | SIGMAR1CASRGAAATMACP3 | |
| SCHEMBL8437895 | 0.82 | SIGMAR1 (0.61) | SIGMAR1CASRGAAATMACP3 | |
| SCHEMBL12154026 | 0.82 | CASR (0.63) | SIGMAR1CASRGPR35ACP3LMNA | |
| SCHEMBL14210385 | 0.82 | CASR (0.63) | SIGMAR1CASRGPR35ACP3LMNA | |
| SCHEMBL4670006 | 0.81 | TSHR (0.42) | NR1H4GAATDP1LMNANR1I2 | |
| SCHEMBL12974482 | 0.81 | ALDH1A1 (0.59) | NR1H4GAATDP1ATMLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7550499-B2 | Urea antagonists of P2Y1 receptor useful in the treatment of thrombotic conditions | BRISTOL-MYERS SQUIBB COMPANY (US) | 2009-06-23 | — | — | US | disclosed |