Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCL1 | Q07820 | 1/20 | 0.54 |
| ▸ | MRGPRX4 | Q96LA9 | 4/20 | 0.53 |
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | PTGER1 | P34995 | 3/20 | 0.50 |
| ▸ | PTGER4 | P35408 | 2/20 | 0.50 |
| ▸ | PTGER3 | P43115 | 2/20 | 0.50 |
| ▸ | PTGER2 | P43116 | 2/20 | 0.50 |
| ▸ | MAOB | P27338 | 1/20 | 0.50 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.48 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.48 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.47 |
| ▸ | GLRA1 | P23415 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21327456 | 0.88 | LRRK2 (0.57) | MCL1MRGPRX4MAPTTDP1L3MBTL1 | |
| SCHEMBL8168015 | 0.88 | MCL1 (0.64) | MCL1MRGPRX4MAPTTDP1L3MBTL1 | |
| SCHEMBL6450060 | 0.87 | MAPT (0.63) | MCL1MRGPRX4MAPTTDP1L3MBTL1 | |
| SCHEMBL4939266 | 0.85 | MAOB (0.60) | MCL1CYP2C19SMN1; SMN2MAOB | |
| SCHEMBL5228333 | 0.84 | HDAC8 (0.57) | MCL1MRGPRX4MAPTCYP2C9CYP2C19 | |
| SCHEMBL31375951 | 0.84 | PTGER1 (0.58) | MCL1MRGPRX4CYP2C9SMN1; SMN2PTGER1 | |
| SCHEMBL27486908 | 0.83 | AKR1C3 (0.49) | MCL1MRGPRX4MAPTTDP1L3MBTL1 | |
| SCHEMBL21327204 | 0.82 | MCL1 (0.54) | MCL1MRGPRX4MAPTTDP1L3MBTL1 | |
| SCHEMBL19361431 | 0.82 | PTGES (0.52) | MCL1PTGER1MAOBLRRK2FOLH1 | |
| SCHEMBL5296788 | 0.82 | KMT2A (0.58) | MAPTL3MBTL1SMN1; SMN2PTGER1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8309578-B2 | Bicyclic pyrazole and isoxazole derivatives as antitumor and antineurodegenerative agents | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2012-11-13 | — | — | US | disclosed |
| US-20110294790-A1 | BICYCLIC PYRAZOLE AND ISOXAZOLE DERIVATIVES AS ANTITUMOR AND ANTINEURODEGENERATIVE AGENTS | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2011-12-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110294790-A1 | BICYCLIC PYRAZOLE AND ISOXAZOLE DERIVATIVES AS ANTITUMOR AND ANTINEURODEGENERATIVE AGENTS | HSP90AB1, HSP90AA1, HSP90AB2P | MCL1 194/4885MRGPRX4 3064/4885MAPT 157/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.