Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GCK | P35557 | 13/20 | 0.57 |
| ▸ | GAA | P10253 | 3/20 | 0.52 |
| ▸ | RAB9A | P51151 | 2/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | NPC1 | O15118 | 1/20 | 0.51 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | GRM5 | P41594 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13822848 | 0.84 | RAB9A (0.45) | GCKGAARAB9AKMT2AMEN1 | |
| SCHEMBL2669505 | 0.81 | MAPT (0.43) | GCKGAARAB9AKMT2AMEN1 | |
| SCHEMBL190659 | 0.81 | GCK (0.59) | GCKGAARAB9AKMT2AMEN1 | |
| SCHEMBL3040689 | 0.78 | GAA (0.52) | GCKGAARAB9ANPC1ALDH1A1 | |
| SCHEMBL2657937 | 0.77 | MAPT (0.53) | GCKGAARAB9AKMT2AMEN1 | |
| SCHEMBL14742770 | 0.77 | RAB9A (0.65) | GCKGAARAB9AKMT2AMEN1 | |
| SCHEMBL190118 | 0.77 | GCK (0.55) | GCKGAARAB9AKMT2ANPC1 | |
| SCHEMBL2658280 | 0.77 | SCN9A (0.47) | RAB9AKMT2AMEN1NPC1ALDH1A1 | |
| SCHEMBL2668080 | 0.77 | GCK (0.56) | GCKGAARAB9AKMT2A | |
| SCHEMBL190773 | 0.77 | GCK (0.56) | GCKGAARAB9AKMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2195312-B1 | PYRIDINE DERIVATIVES USEFUL AS GLUCOKINASE ACTIVATORS | MERCK PATENT GMBH (DE) | 2012-11-21 | — | — | EP | claimed |