Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 8/20 | 0.45 |
| ▸ | NPC1 | O15118 | 7/20 | 0.45 |
| ▸ | MEN1 | O00255 | 7/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.45 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.43 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | SLC2A1 | P11166 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 4/20 | 0.40 |
| ▸ | GCK | P35557 | 3/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.40 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.40 |
| ▸ | RELA | Q04206 | 2/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | PTGES | O14684 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13822849 | 0.84 | GCK (0.57) | RAB9ANPC1MEN1KMT2ATRPV4 | |
| SCHEMBL2669505 | 0.81 | MAPT (0.43) | RAB9ANPC1MEN1KMT2APTGS2 | |
| SCHEMBL3040689 | 0.81 | GAA (0.52) | RAB9ANPC1GAAALDH1A1MAPT | |
| SCHEMBL2658280 | 0.77 | SCN9A (0.47) | RAB9ANPC1MEN1KMT2AALDH1A1 | |
| SCHEMBL2657937 | 0.75 | MAPT (0.53) | RAB9ANPC1MEN1KMT2AGAA | |
| SCHEMBL13822770 | 0.75 | MEN1 (0.42) | RAB9ANPC1MEN1KMT2ATRPV4 | |
| Acetic Acid SCHEMBL3040692 | 0.71 | RAB9A (0.47) | RAB9ANPC1MEN1KMT2APTGS2 | |
| SCHEMBL9342694 | 0.69 | LTA4H (0.50) | ALDH1A1HTT | |
| SCHEMBL14742721 | 0.68 | GAA (0.72) | RAB9ANPC1MEN1KMT2APTGS2 | |
| SCHEMBL9267486 | 0.67 | NPC1 (0.42) | RAB9ANPC1MEN1KMT2AGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2195312-B1 | PYRIDINE DERIVATIVES USEFUL AS GLUCOKINASE ACTIVATORS | MERCK PATENT GMBH (DE) | 2012-11-21 | — | — | EP | claimed |