Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 5/20 | 0.52 |
| ▸ | MAPT | P10636 | 5/20 | 0.49 |
| ▸ | PDE5A | O76074 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 3/20 | 0.46 |
| ▸ | RAB9A | P51151 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.46 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.46 |
| ▸ | RELA | Q04206 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | GCK | P35557 | 1/20 | 0.44 |
| ▸ | MME | P08473 | 2/20 | 0.43 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | CCNK | O75909 | 1/20 | 0.41 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.41 |
| ▸ | CDK12 | Q9NYV4 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2669505 | 0.87 | MAPT (0.43) | GAAMAPTPDE5ANPC1RAB9A | |
| SCHEMBL2657937 | 0.85 | MAPT (0.53) | GAAMAPTPDE5ANPC1RAB9A | |
| SCHEMBL13822848 | 0.81 | RAB9A (0.45) | GAAMAPTNPC1RAB9AALDH1A1 | |
| SCHEMBL3043516 | 0.80 | GAA (0.51) | GAAMAPTPDE5ANPC1RAB9A | |
| SCHEMBL13822849 | 0.78 | GCK (0.57) | GAAMAPTNPC1RAB9AALDH1A1 | |
| SCHEMBL3611513 | 0.76 | ALDH1A1 (0.62) | GAAALDH1A1SMN1; SMN2POLBHPGD | |
| SCHEMBL1329122 | 0.75 | GCK (0.67) | GAAMAPTPDE5AGCK | |
| SCHEMBL12050121 | 0.75 | ALDH1A1 (0.68) | GAAMAPTPDE5ANPC1RAB9A | |
| SCHEMBL12050096 | 0.74 | MAPT (0.59) | GAAMAPTPDE5ANPC1RAB9A | |
| SCHEMBL11587669 | 0.72 | GAA (0.63) | GAAMAPTPDE5AALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8420642-B2 | Pyridine derivatives useful as glucokinase activators | MERCK PATENT GMBH (DE) | 2013-04-16 | — | — | US | claimed |
| US-20100216794-A1 | PYRIDINE DERIVATIVES USEFUL AS GLUCOKINASE ACTIVATORS | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2010-08-26 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100216794-A1 | PYRIDINE DERIVATIVES USEFUL AS GLUCOKINASE ACTIVATORS | HK1, GCKR, GCK | GAA 564/4885MAPT 2751/4885PDE5A 2629/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.