Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 8/20 | 0.53 |
| ▸ | MTNR1B | P49286 | 5/20 | 0.53 |
| ▸ | RAB9A | P51151 | 2/20 | 0.53 |
| ▸ | LMNA | P02545 | 3/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | HPGD | P15428 | 1/20 | 0.52 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.52 |
| ▸ | BLM | P54132 | 1/20 | 0.52 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.52 |
| ▸ | POLB | P06746 | 2/20 | 0.52 |
| ▸ | NPC1 | O15118 | 1/20 | 0.52 |
| ▸ | ACACB | O00763 | 1/20 | 0.50 |
| ▸ | F13A1 | P00488 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | THRB | P10828 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20563412 | 0.87 | NPC1 (0.56) | RAB9ALMNAALDH1A1MAPTPOLB | |
| SCHEMBL15384437 | 0.84 | LMNA (0.64) | MTNR1ARAB9ALMNAKDM4EHSD17B10 | |
| SCHEMBL30627588 | 0.82 | RAB9A (0.50) | RAB9ALMNAALDH1A1MAPTPOLB | |
| SCHEMBL1405119 | 0.81 | RAB9A (0.50) | RAB9ALMNAKDM4EMAPTPOLB | |
| SCHEMBL9426372 | 0.81 | POLB (0.46) | RAB9ALMNAKDM4EHSD17B10ALDH1A1 | |
| SCHEMBL20564767 | 0.80 | NPC1 (0.49) | RAB9ALMNAALDH1A1MAPTPOLB | |
| SCHEMBL6321282 | 0.79 | LMNA (0.55) | RAB9ALMNAALDH1A1MAPTHPGD | |
| SCHEMBL24514159 | 0.79 | KMT2A (0.57) | RAB9AALDH1A1MAPTPOLBNPC1 | |
| SCHEMBL11744707 | 0.78 | HSD17B10 (0.70) | RAB9ALMNAKDM4EHSD17B10ALDH1A1 | |
| SCHEMBL1390658 | 0.78 | SMN1; SMN2 (0.47) | RAB9ALMNAKDM4EHSD17B10ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-4739625-B2 | — | — | 2011-08-03 | — | — | JP | claimed |
| EP-1206467-A1 | N-HETEROCYCLIC DERIVATIVES AS NOS INHIBITORS | BERLEX LABORATORIES, INC. (US) | 2002-05-22 | — | — | EP | disclosed |
| WO-2001014371-A1 | N-HETEROCYCLIC DERIVATIVES AS NOS INHIBITORS | BERLEX LABORATORIES, INC. (US) | 2001-03-01 | — | — | WO | disclosed |