Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 12/20 | 0.39 |
| ▸ | DRD3 | P35462 | 5/20 | 0.39 |
| ▸ | DRD4 | P21917 | 3/20 | 0.39 |
| ▸ | HTR1A | P08908 | 1/20 | 0.38 |
| ▸ | DRD1 | P21728 | 1/20 | 0.38 |
| ▸ | DRD5 | P21918 | 1/20 | 0.38 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.38 |
| ▸ | HTR2A | P28223 | 1/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.38 |
| ▸ | HTR7 | P34969 | 1/20 | 0.38 |
| ▸ | HRH1 | P35367 | 1/20 | 0.38 |
| ▸ | HTR2B | P41595 | 1/20 | 0.38 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.37 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.34 |
| ▸ | S1PR1 | P21453 | 2/20 | 0.34 |
| ▸ | S1PR3 | Q99500 | 2/20 | 0.34 |
| ▸ | S1PR5 | Q9H228 | 2/20 | 0.34 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10288248 | 0.91 | DRD2 (0.40) | DRD2DRD3DRD4HTR1ADRD1 | |
| SCHEMBL10287553 | 0.91 | DRD2 (0.41) | DRD2DRD3DRD4HTR1ADRD1 | |
| SCHEMBL13617515 | 0.91 | DRD2 (0.41) | DRD2DRD3DRD4HTR1ADRD1 | |
| SCHEMBL12121927 | 0.91 | DRD2 (0.41) | DRD2DRD3DRD4HTR1ADRD1 | |
| SCHEMBL13824438 | 0.91 | DRD2 (0.35) | DRD2DRD3DRD4HTR1ADRD1 | |
| SCHEMBL12121724 | 0.90 | DRD2 (0.39) | DRD2DRD3DRD4HTR1ADRD1 | |
| SCHEMBL13616961 | 0.90 | DRD2 (0.36) | DRD2DRD3DRD4HTR1ADRD1 | |
| SCHEMBL12121939 | 0.89 | DRD2 (0.38) | DRD2DRD3DRD4HTR1ADRD1 | |
| SCHEMBL13824223 | 0.89 | DRD2 (0.38) | DRD2DRD3DRD4HTR1ADRD1 | |
| SCHEMBL10288236 | 0.88 | ALDH1A1 (0.41) | DRD2DRD3HTR1ADRD1DRD5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7541365-B2 | Chemokine receptor antagonists and methods of use therefor | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2009-06-02 | — | — | US | disclosed |