Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 9/20 | 0.38 |
| ▸ | OPRM1 | P35372 | 5/20 | 0.36 |
| ▸ | DRD4 | P21917 | 4/20 | 0.36 |
| ▸ | ADRA2A | P08913 | 3/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | ADRB2 | P07550 | 2/20 | 0.36 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.36 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.36 |
| ▸ | HTR2B | P41595 | 2/20 | 0.36 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.36 |
| ▸ | HRH2 | P25021 | 2/20 | 0.36 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.36 |
| ▸ | DRD3 | P35462 | 2/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.36 |
| ▸ | SCN5A | Q14524 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13824226 | 0.93 | CCR1 (0.38) | DRD2OPRM1DRD4DRD3ABCB11 | |
| SCHEMBL12121715 | 0.93 | CCR1 (0.37) | DRD2OPRM1DRD4ADRA2ASLC6A4 | |
| SCHEMBL10288236 | 0.90 | ALDH1A1 (0.41) | DRD2SLC6A4MEN1LMNAHTR2B | |
| SCHEMBL13617080 | 0.90 | DRD2 (0.36) | DRD2DRD4SLC6A4LMNAHTR2B | |
| SCHEMBL13824263 | 0.89 | DRD2 (0.39) | DRD2OPRM1DRD4SLC6A4HTR2B | |
| SCHEMBL13824224 | 0.88 | MCHR1 (0.34) | DRD2DRD4MEN1KMT2ADRD3 | |
| SCHEMBL10287605 | 0.88 | DRD2 (0.41) | DRD2OPRM1DRD4SLC6A4HTR2B | |
| SCHEMBL10288248 | 0.88 | DRD2 (0.40) | DRD2DRD4SLC6A4MEN1LMNA | |
| SCHEMBL13824429 | 0.88 | ALDH1A1 (0.39) | DRD2SLC6A4MEN1LMNAHTR2B | |
| SCHEMBL13616961 | 0.88 | DRD2 (0.36) | DRD2DRD4SLC6A4LMNAHTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7541365-B2 | Chemokine receptor antagonists and methods of use therefor | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2009-06-02 | — | — | US | disclosed |