Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTK | P29376 | 2/20 | 0.50 |
| ▸ | ALK | Q9UM73 | 2/20 | 0.50 |
| ▸ | DYRK1B | Q9Y463 | 2/20 | 0.50 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.50 |
| ▸ | RET | P07949 | 1/20 | 0.50 |
| ▸ | MET | P08581 | 1/20 | 0.50 |
| ▸ | GRK5 | P34947 | 1/20 | 0.50 |
| ▸ | CDK8 | P49336 | 1/20 | 0.50 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.50 |
| ▸ | MST1R | Q04912 | 1/20 | 0.50 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.50 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.50 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.50 |
| ▸ | PDE5A | O76074 | 3/20 | 0.46 |
| ▸ | PDE3B | Q13370 | 4/20 | 0.42 |
| ▸ | PDE3A | Q14432 | 4/20 | 0.42 |
| ▸ | CHEK1 | O14757 | 4/20 | 0.38 |
| ▸ | KDR | P35968 | 2/20 | 0.38 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.38 |
| ▸ | ABL1 | P00519 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13824906 | 0.81 | RET (0.42) | LTKALKDYRK1BCLK4RET | |
| SCHEMBL13825028 | 0.79 | LTK (0.48) | LTKALKDYRK1BCLK4RET | |
| SCHEMBL13825030 | 0.77 | LTK (0.46) | LTKALKDYRK1BCLK4RET | |
| SCHEMBL13933585 | 0.77 | LTK (0.44) | LTKALKDYRK1BCLK4RET | |
| SCHEMBL13825035 | 0.74 | HPGDS (0.48) | PDE3BPDE3ACSNK1D | |
| SCHEMBL4511564 | 0.71 | POLB (0.40) | LTKALKDYRK1BCLK4RET | |
| SCHEMBL18632535 | 0.68 | SCN5A (0.62) | LTKALKDYRK1BCLK4RET | |
| SCHEMBL18632530 | 0.68 | SCN5A (0.62) | LTKALKDYRK1BCLK4RET | |
| SCHEMBL18632538 | 0.67 | SCN5A (0.57) | LTKALKDYRK1BCLK4RET | |
| SCHEMBL13825172 | 0.66 | KDM4E (0.35) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012150829-A2 | NOBLE TRIAZOLOPYRIDINE DERIVATIVE OR PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF, PRODUCTION METHOD THEREOF, AND PHARMACEUTICAL COMPOSITION INCLUDING SAME | 제일약품주식회사 (KR) | 2012-11-08 | — | — | WO | disclosed |