Sugi Predict

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SCHEMBL13828327

SCHEMBL13828327

Cc1n[nH]c2cc(-c3nn(C)c4ncnc(N5CCOCC5)c34)ccc12

nearest known ligand 0.49

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
▸ PDE2A O00408 8/20 0.49
▸ LRRK2 Q5S007 7/20 0.43
▸ PIK3CD O00329 2/20 0.43
▸ ABL1 P00519 2/20 0.43
▸ EGFR P00533 2/20 0.43
▸ HCK P08631 2/20 0.43
▸ SRC P12931 2/20 0.43
▸ KDR P35968 2/20 0.43
▸ PIK3CA P42336 2/20 0.43
▸ PIK3CB P42338 2/20 0.43
▸ MTOR P42345 2/20 0.43
▸ PIK3CG P48736 2/20 0.43
▸ EPHB4 P54760 2/20 0.43
▸ PRKDC P78527 2/20 0.43
▸ MEN1 O00255 1/20 0.42
▸ KMT2A Q03164 1/20 0.42
▸ ADK P55263 1/20 0.42
▸ PDPK1 O15530 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL13826604 0.83 LRRK2 (0.47) LRRK2PDPK1
SCHEMBL129811 0.80 PIK3CD (0.63) PIK3CDABL1EGFRHCKSRC
SCHEMBL13718701 0.72 PIK3CD (0.51) LRRK2PIK3CDABL1EGFRHCK
SCHEMBL13828341 0.72 PDE2A (0.49) PDE2ALRRK2PIK3CDABL1EGFR
SCHEMBL13826047 0.72 PIK3CD (0.60) PIK3CDABL1EGFRHCKSRC
SCHEMBL13828432 0.69 PDE2A (0.45) PDE2ALRRK2PIK3CAMTORPIK3CG
SCHEMBL22275887 0.68 NUDT14 (0.57) PDE2APIK3CDABL1EGFRHCK
SCHEMBL129826 0.67 PIK3CD (0.60) PIK3CDABL1EGFRHCKSRC
SCHEMBL13828372 0.67 PIK3CA (0.55) PIK3CDABL1EGFRHCKSRC
SCHEMBL11721437 0.67 PDE2A (0.47) PDE2AMEN1KMT2AADK

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-10220035-B2 Compounds as modulators of protein kinases RHIZEN PHARMACEUTICALS SA (CH) 2019-03-05 — — US disclosed
US-20180110783-A1 NOVEL COMPOUNDS AS MODULATORS OF PROTEIN KINASES RHIZEN PHARMACEUTICALS SA (CH) 2018-04-26 — — US disclosed
US-9775841-B2 Compounds as modulators of protein kinases RHIZEN PHARMACEUTICALS SA (CH) 2017-10-03 — — US disclosed
US-20150320752-A1 NOVEL COMPOUNDS AS MODULATORS OF PROTEIN KINASES RHIZEN PHARMACEUTICALS AG (CH) 2015-11-12 — — US disclosed
US-20120289496-A1 NOVEL COMPOUNDS AS MODULATORS OF PROTEIN KINASES RHIZEN PHARMACEUTICALS SA (CH) 2012-11-15 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20150320752-A1 NOVEL COMPOUNDS AS MODULATORS OF PROTEIN KINASES PRKCA, PRKCH, PRKCB PDE2A 803/4885LRRK2 317/4885PIK3CD 47/4885
US-20120289496-A1 NOVEL COMPOUNDS AS MODULATORS OF PROTEIN KINASES PRKCA, PRKCH, PRKCB PDE2A 803/4885LRRK2 317/4885PIK3CD 47/4885
US-10220035-B2 Compounds as modulators of protein kinases PRKCA, PRKCH, PRKCE PDE2A 752/4885LRRK2 376/4885PIK3CD 30/4885
US-20180110783-A1 NOVEL COMPOUNDS AS MODULATORS OF PROTEIN KINASES PRKCA, PRKCH, PRKCB PDE2A 803/4885LRRK2 317/4885PIK3CD 47/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.