Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRC | P12931 | 15/20 | 0.76 |
| ▸ | PIK3CD | O00329 | 12/20 | 0.76 |
| ▸ | PIK3CA | P42336 | 12/20 | 0.76 |
| ▸ | PIK3CG | P48736 | 12/20 | 0.76 |
| ▸ | PRKDC | P78527 | 12/20 | 0.76 |
| ▸ | KDR | P35968 | 11/20 | 0.76 |
| ▸ | ABL1 | P00519 | 11/20 | 0.76 |
| ▸ | EGFR | P00533 | 11/20 | 0.76 |
| ▸ | HCK | P08631 | 11/20 | 0.76 |
| ▸ | MTOR | P42345 | 11/20 | 0.76 |
| ▸ | EPHB4 | P54760 | 11/20 | 0.76 |
| ▸ | PI4KB | Q9UBF8 | 5/20 | 0.76 |
| ▸ | PIK3CB | P42338 | 10/20 | 0.64 |
| ▸ | AURKA | O14965 | 1/20 | 0.56 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.56 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.56 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.52 |
| ▸ | TEK | Q02763 | 1/20 | 0.52 |
| ▸ | NUDT14 | O95848 | 1/20 | 0.50 |
| ▸ | NUDT5 | Q9UKK9 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2432675 | 0.86 | SRC (1.00) | SRCPIK3CDPIK3CAPIK3CGPRKDC | |
| SCHEMBL18874138 | 0.84 | PIK3CD (0.55) | SRCPIK3CDPIK3CAPIK3CGPRKDC | |
| SCHEMBL17970700 | 0.82 | AURKA (0.67) | SRCPIK3CDPIK3CAPIK3CGPRKDC | |
| SCHEMBL130421 | 0.80 | PIK3CD (0.78) | SRCPIK3CDPIK3CAPIK3CGPRKDC | |
| SCHEMBL4045710 | 0.79 | TYRO3 (0.53) | SRCPIK3CDPIK3CAPIK3CGPRKDC | |
| SCHEMBL129820 | 0.78 | PIK3CD (0.76) | SRCPIK3CDPIK3CAPIK3CGPRKDC | |
| SCHEMBL21105366 | 0.78 | KDR (0.61) | SRCPIK3CDPIK3CAPIK3CGPRKDC | |
| SCHEMBL130589 | 0.77 | PIK3CG (0.74) | SRCPIK3CDPIK3CAPIK3CGPRKDC | |
| SCHEMBL12351 | 0.77 | PIK3CD (0.74) | SRCPIK3CDPIK3CAPIK3CGPRKDC | |
| SCHEMBL409367 | 0.76 | PIK3CD (0.82) | SRCPIK3CDPIK3CAPIK3CGPRKDC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20190282581-A1 | NOVEL COMPOUNDS AS MODULATORS OF PROTEIN KINASES | RHIZEN PHARMACEUTICALS AG (CH) | 2019-09-19 | — | — | US | disclosed |
| US-10322130-B2 | Substituted chromenones as modulators of protein kinases | RHIZEN PHARMACEUTICALS SA (CH) | 2019-06-18 | — | — | US | disclosed |
| US-20190105324-A9 | SUBSTITUTED CHROMENONES AS MODULATORS OF PROTEIN KINASES | RHIZEN PHARMACEUTICALS AG (CH) | 2019-04-11 | — | — | US | disclosed |
| US-10220035-B2 | Compounds as modulators of protein kinases | RHIZEN PHARMACEUTICALS SA (CH) | 2019-03-05 | — | — | US | disclosed |
| US-20180110783-A1 | NOVEL COMPOUNDS AS MODULATORS OF PROTEIN KINASES | RHIZEN PHARMACEUTICALS SA (CH) | 2018-04-26 | — | — | US | disclosed |
| US-20180110783-A1 | NOVEL COMPOUNDS AS MODULATORS OF PROTEIN KINASES | RHIZEN PHARMACEUTICALS SA (CH) | 2018-04-26 | — | — | US | disclosed |
| US-9775841-B2 | Compounds as modulators of protein kinases | RHIZEN PHARMACEUTICALS SA (CH) | 2017-10-03 | — | — | US | disclosed |
| US-20150320752-A1 | NOVEL COMPOUNDS AS MODULATORS OF PROTEIN KINASES | RHIZEN PHARMACEUTICALS AG (CH) | 2015-11-12 | — | — | US | disclosed |
| US-20120289496-A1 | NOVEL COMPOUNDS AS MODULATORS OF PROTEIN KINASES | RHIZEN PHARMACEUTICALS SA (CH) | 2012-11-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150320752-A1 | NOVEL COMPOUNDS AS MODULATORS OF PROTEIN KINASES | PRKCA, PRKCH, PRKCB | SRC 285/4885PIK3CD 47/4885PIK3CA 88/4885 |
| US-20120289496-A1 | NOVEL COMPOUNDS AS MODULATORS OF PROTEIN KINASES | PRKCA, PRKCH, PRKCB | SRC 285/4885PIK3CD 47/4885PIK3CA 88/4885 |
| US-20190105324-A9 | SUBSTITUTED CHROMENONES AS MODULATORS OF PROTEIN KINASES | PRKCA, PRKCH, PRKAR2B | SRC 254/4885PIK3CD 89/4885PIK3CA 106/4885 |
| US-10220035-B2 | Compounds as modulators of protein kinases | PRKCA, PRKCH, PRKCE | SRC 205/4885PIK3CD 30/4885PIK3CA 64/4885 |
| US-20180110783-A1 | NOVEL COMPOUNDS AS MODULATORS OF PROTEIN KINASES | PRKCA, PRKCH, PRKCB | SRC 285/4885PIK3CD 47/4885PIK3CA 88/4885 |
| US-20190282581-A1 | NOVEL COMPOUNDS AS MODULATORS OF PROTEIN KINASES | PRKCA, PRKCH, PRKCB | SRC 285/4885PIK3CD 47/4885PIK3CA 88/4885 |
| US-10322130-B2 | Substituted chromenones as modulators of protein kinases | MAP3K1, CSNK1A1, MAP3K2 | SRC 90/4885PIK3CD 148/4885PIK3CA 153/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.