Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.39 |
| ▸ | CXCR2 | P25025 | 2/20 | 0.38 |
| ▸ | CXCR1 | P25024 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | GMNN | O75496 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | TACR1 | P25103 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | CA1 | P00915 | 1/20 | 0.34 |
| ▸ | CA2 | P00918 | 1/20 | 0.34 |
| ▸ | CA5A | P35218 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28419506 | 1.00 | HCAR2 (0.39) | HCAR2CXCR2CXCR1KMT2AALDH1A1 | |
| Ammonia Solution, Strong SCHEMBL28355285 | 0.98 | HCAR2 (0.38) | HCAR2CXCR2CXCR1KMT2AALDH1A1 | |
| SCHEMBL8258576 | 0.85 | CXCR2 (0.39) | CXCR2CXCR1KMT2AALDH1A1NPSR1 | |
| SCHEMBL13829065 | 0.85 | CXCR2 (0.39) | CXCR2CXCR1KMT2AALDH1A1NPSR1 | |
| SCHEMBL29856072 | 0.80 | IDO1 (0.40) | KMT2AALDH1A1MAPTNPSR1MAPK1 | |
| Ammonia Solution, Strong SCHEMBL29119872 | 0.78 | IDO1 (0.39) | KMT2AALDH1A1MAPTNPSR1LMNA | |
| SCHEMBL7688541 | 0.78 | ALDH1A1 (0.42) | HCAR2KMT2AALDH1A1MAPTNPSR1 | |
| SCHEMBL8241125 | 0.78 | ALDH1A1 (0.42) | HCAR2KMT2AALDH1A1MAPTNPSR1 | |
| SCHEMBL8115614 | 0.78 | ALDH1A1 (0.42) | HCAR2KMT2AALDH1A1MAPTNPSR1 | |
| SCHEMBL12800458 | 0.77 | NPSR1 (0.39) | CXCR2KMT2AALDH1A1MAPTNPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120289523-A1 | PYRROLO [3,2-E] [1,2,4] TRIAZOLO [1,5-A] PYRIMIDINES DERIVATIVES AS INHIBITORS OF MICROGLIA ACTIVATION | BTG INTERNATIONAL LIMITED (GB) | 2012-11-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120289523-A1 | PYRROLO [3,2-E] [1,2,4] TRIAZOLO [1,5-A] PYRIMIDINES DERIVATIVES AS INHIBITORS OF MICROGLIA ACTIVATION | CX3CR1, CSF1R, PSEN1 | HCAR2 269/4885CXCR2 16/4885CXCR1 22/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.