Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 7/20 | 0.53 |
| ▸ | EGFR | P00533 | 4/20 | 0.49 |
| ▸ | ITK | Q08881 | 3/20 | 0.49 |
| ▸ | AURKA | O14965 | 5/20 | 0.46 |
| ▸ | KDR | P35968 | 4/20 | 0.46 |
| ▸ | PLK1 | P53350 | 4/20 | 0.46 |
| ▸ | INSR | P06213 | 2/20 | 0.46 |
| ▸ | PTK2 | Q05397 | 2/20 | 0.46 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.46 |
| ▸ | JAK2 | O60674 | 2/20 | 0.46 |
| ▸ | JAK1 | P23458 | 2/20 | 0.46 |
| ▸ | JAK3 | P52333 | 2/20 | 0.46 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.46 |
| ▸ | TYRO3 | Q06418 | 2/20 | 0.46 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.46 |
| ▸ | CDC7 | O00311 | 1/20 | 0.46 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.46 |
| ▸ | PLK4 | O00444 | 1/20 | 0.46 |
| ▸ | STK25 | O00506 | 1/20 | 0.46 |
| ▸ | CIT | O14578 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19297725 | 0.94 | SYK (0.56) | SYKEGFRITKAURKAKDR | |
| SCHEMBL19297718 | 0.88 | SYK (0.48) | SYKEGFRITKAURKAPLK1 | |
| SCHEMBL1381667 | 0.86 | SYK (0.51) | SYKEGFRITKAURKAKDR | |
| SCHEMBL19297754 | 0.86 | BCL6 (0.58) | SYKEGFRPTK2STK17BSTK17A | |
| SCHEMBL19297722 | 0.86 | SYK (0.57) | SYKEGFRAURKAPLK1JAK2 | |
| SCHEMBL1384407 | 0.84 | SYK (0.68) | SYKEGFRITKAURKAKDR | |
| SCHEMBL19297749 | 0.84 | AURKA (0.52) | SYKEGFRAURKACDK1PTK2B | |
| SCHEMBL1383865 | 0.83 | SYK (0.52) | SYKEGFRITKAURKAKDR | |
| SCHEMBL19297717 | 0.81 | SYK (0.69) | SYKAURKAAURKBMAPK8 | |
| SCHEMBL14837242 | 0.80 | SYK (0.56) | SYKEGFRITKAURKAKDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 24 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1984357-B1 | 2,4-PYRIMIDINEDIAMINE COMPOUNDS FOR TREATING OR PREVENTING AUTOIMMUNE DISEASES | RIGEL PHARMACEUTICALS INC (US) | 2013-10-02 | — | — | EP | claimed |
| JP-4653842-B2 | — | — | 2011-03-16 | — | — | JP | claimed |
| US-7659280-B2 | 2,4-pyrimidinediamine compounds for treating or preventing autoimmune diseases | RIGEL PHARMACEUTICALS, INC. (US) | 2010-02-09 | — | — | US | claimed |
| JP-2009527496-A | — | — | 2009-07-30 | — | — | JP | claimed |
| EP-1984357-A2 | 2,4-PYRIMIDINEDIAMINE COMPOUNDS FOR TREATING OR PREVENTING AUTOIMMUNE DISEASES | Rigel Pharmaceuticals, Inc. (US) | 2008-10-29 | — | — | EP | claimed |
| WO-2007120980-A2 | 2,4-PYRIMIDINEDIAMINE COMPOUNDS FOR TREATING OR PREVENTING AUTOIMMUNE DISEASES | RIGEL PHARMACEUTICALS, INC. (US) | 2007-10-25 | — | — | WO | claimed |
| US-20070197782-A1 | 2,4-PYRIMIDINEDIAMINE COMPOUNDS FOR TREATING OR PREVENTING AUTOIMMUNE DISEASES | RIGEL PHARMACEUTICALS, INC. | 2007-08-23 | — | — | US | claimed |
| EP-1984357-B1 | 2,4-PYRIMIDINEDIAMINE COMPOUNDS FOR TREATING OR PREVENTING AUTOIMMUNE DISEASES | RIGEL PHARMACEUTICALS INC (US) | 2013-10-02 | — | — | EP | disclosed |
| EP-1984357-B1 | 2,4-PYRIMIDINEDIAMINE COMPOUNDS FOR TREATING OR PREVENTING AUTOIMMUNE DISEASES | RIGEL PHARMACEUTICALS INC (US) | 2013-10-02 | — | — | EP | disclosed |
| US-8314093-B2 | 2,4-pyrimidinediamine compounds for treating or preventing autoimmune diseases | RIGEL PHARMACEUTICALS, INC. (US) | 2012-11-20 | — | — | US | disclosed |
| US-8314093-B2 | 2,4-pyrimidinediamine compounds for treating or preventing autoimmune diseases | RIGEL PHARMACEUTICALS, INC. (US) | 2012-11-20 | — | — | US | disclosed |
| US-8314093-B2 | 2,4-pyrimidinediamine compounds for treating or preventing autoimmune diseases | RIGEL PHARMACEUTICALS, INC. (US) | 2012-11-20 | — | — | US | disclosed |
| US-20100152172-A1 | 2,4-PYRIMIDINEDIAMINE COMPOUNDS FOR TREATING OR PREVENTING AUTOIMMUNE DISEASES | RIGEL PHARMACEUTICALS, INC. | 2010-06-17 | — | — | US | disclosed |
| US-7659280-B2 | 2,4-pyrimidinediamine compounds for treating or preventing autoimmune diseases | RIGEL PHARMACEUTICALS, INC. (US) | 2010-02-09 | — | — | US | disclosed |
| EP-1984357-A2 | 2,4-PYRIMIDINEDIAMINE COMPOUNDS FOR TREATING OR PREVENTING AUTOIMMUNE DISEASES | Rigel Pharmaceuticals, Inc. (US) | 2008-10-29 | — | — | EP | disclosed |
| WO-2007120980-A2 | 2,4-PYRIMIDINEDIAMINE COMPOUNDS FOR TREATING OR PREVENTING AUTOIMMUNE DISEASES | RIGEL PHARMACEUTICALS, INC. (US) | 2007-10-25 | — | — | WO | disclosed |
| WO-2007120980-A2 | 2,4-PYRIMIDINEDIAMINE COMPOUNDS FOR TREATING OR PREVENTING AUTOIMMUNE DISEASES | RIGEL PHARMACEUTICALS, INC. (US) | 2007-10-25 | — | — | WO | disclosed |
| US-20070197782-A1 | 2,4-PYRIMIDINEDIAMINE COMPOUNDS FOR TREATING OR PREVENTING AUTOIMMUNE DISEASES | RIGEL PHARMACEUTICALS, INC. | 2007-08-23 | — | — | US | disclosed |
| US-20070197782-A1 | 2,4-PYRIMIDINEDIAMINE COMPOUNDS FOR TREATING OR PREVENTING AUTOIMMUNE DISEASES | RIGEL PHARMACEUTICALS, INC. | 2007-08-23 | — | — | US | disclosed |
| US-20070197782-A1 | 2,4-PYRIMIDINEDIAMINE COMPOUNDS FOR TREATING OR PREVENTING AUTOIMMUNE DISEASES | RIGEL PHARMACEUTICALS, INC. | 2007-08-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070197782-A1 | 2,4-PYRIMIDINEDIAMINE COMPOUNDS FOR TREATING OR PREVENTING AUTOIMMUNE DISEASES | TPMT, SSB, HLA-DRB1 | SYK 1651/4885EGFR 4464/4885ITK 3067/4885 |
| US-20100152172-A1 | 2,4-PYRIMIDINEDIAMINE COMPOUNDS FOR TREATING OR PREVENTING AUTOIMMUNE DISEASES | TPMT, SSB, HLA-DRB1 | SYK 1651/4885EGFR 4464/4885ITK 3067/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.