Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 16/20 | 0.68 |
| ▸ | EGFR | P00533 | 4/20 | 0.52 |
| ▸ | ITK | Q08881 | 3/20 | 0.52 |
| ▸ | JAK1 | P23458 | 2/20 | 0.52 |
| ▸ | JAK3 | P52333 | 2/20 | 0.52 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.52 |
| ▸ | TYRO3 | Q06418 | 2/20 | 0.52 |
| ▸ | PLK4 | O00444 | 2/20 | 0.52 |
| ▸ | AURKA | O14965 | 2/20 | 0.52 |
| ▸ | STK16 | O75716 | 2/20 | 0.52 |
| ▸ | RET | P07949 | 2/20 | 0.52 |
| ▸ | FLT3 | P36888 | 2/20 | 0.52 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.52 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.52 |
| ▸ | MST1R | Q04912 | 2/20 | 0.52 |
| ▸ | PTK2 | Q05397 | 2/20 | 0.52 |
| ▸ | TNK1 | Q13470 | 2/20 | 0.52 |
| ▸ | IKBKE | Q14164 | 2/20 | 0.52 |
| ▸ | MAP3K11 | Q16584 | 2/20 | 0.52 |
| ▸ | ADCK1 | Q86TW2 | 2/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13007745 | 0.86 | SYK (0.54) | SYKEGFRITKJAK1JAK3 | |
| SCHEMBL1380946 | 0.85 | SYK (0.67) | SYKEGFRITKJAK1JAK3 | |
| SCHEMBL1384343 | 0.85 | SYK (0.61) | SYKEGFRITKJAK1JAK3 | |
| SCHEMBL14607335 | 0.85 | SYK (0.67) | SYKJAK1JAK3 | |
| SCHEMBL1382932 | 0.84 | SYK (0.53) | SYKEGFRITKJAK1JAK3 | |
| SCHEMBL190333 | 0.84 | SYK (0.49) | SYKEGFRITKJAK1JAK3 | |
| SCHEMBL656578 | 0.81 | SYK (1.00) | SYKJAK1JAK3AURKAMAPK8 | |
| SCHEMBL30009889 | 0.81 | SYK (1.00) | SYKJAK1JAK3AURKAMAPK8 | |
| SCHEMBL656760 | 0.81 | SYK (1.00) | SYKJAK1JAK3AURKAMAPK8 | |
| SCHEMBL30009410 | 0.81 | SYK (1.00) | SYKJAK1JAK3AURKAMAPK8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 24 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1984357-B1 | 2,4-PYRIMIDINEDIAMINE COMPOUNDS FOR TREATING OR PREVENTING AUTOIMMUNE DISEASES | RIGEL PHARMACEUTICALS INC (US) | 2013-10-02 | — | — | EP | claimed |
| JP-4653842-B2 | — | — | 2011-03-16 | — | — | JP | claimed |
| US-7659280-B2 | 2,4-pyrimidinediamine compounds for treating or preventing autoimmune diseases | RIGEL PHARMACEUTICALS, INC. (US) | 2010-02-09 | — | — | US | claimed |
| JP-2009527496-A | — | — | 2009-07-30 | — | — | JP | claimed |
| EP-1984357-A2 | 2,4-PYRIMIDINEDIAMINE COMPOUNDS FOR TREATING OR PREVENTING AUTOIMMUNE DISEASES | Rigel Pharmaceuticals, Inc. (US) | 2008-10-29 | — | — | EP | claimed |
| WO-2007120980-A2 | 2,4-PYRIMIDINEDIAMINE COMPOUNDS FOR TREATING OR PREVENTING AUTOIMMUNE DISEASES | RIGEL PHARMACEUTICALS, INC. (US) | 2007-10-25 | — | — | WO | claimed |
| US-20070197782-A1 | 2,4-PYRIMIDINEDIAMINE COMPOUNDS FOR TREATING OR PREVENTING AUTOIMMUNE DISEASES | RIGEL PHARMACEUTICALS, INC. | 2007-08-23 | — | — | US | claimed |
| EP-1984357-B1 | 2,4-PYRIMIDINEDIAMINE COMPOUNDS FOR TREATING OR PREVENTING AUTOIMMUNE DISEASES | RIGEL PHARMACEUTICALS INC (US) | 2013-10-02 | — | — | EP | disclosed |
| EP-1984357-B1 | 2,4-PYRIMIDINEDIAMINE COMPOUNDS FOR TREATING OR PREVENTING AUTOIMMUNE DISEASES | RIGEL PHARMACEUTICALS INC (US) | 2013-10-02 | — | — | EP | disclosed |
| US-8314093-B2 | 2,4-pyrimidinediamine compounds for treating or preventing autoimmune diseases | RIGEL PHARMACEUTICALS, INC. (US) | 2012-11-20 | — | — | US | disclosed |
| US-8314093-B2 | 2,4-pyrimidinediamine compounds for treating or preventing autoimmune diseases | RIGEL PHARMACEUTICALS, INC. (US) | 2012-11-20 | — | — | US | disclosed |
| US-8314093-B2 | 2,4-pyrimidinediamine compounds for treating or preventing autoimmune diseases | RIGEL PHARMACEUTICALS, INC. (US) | 2012-11-20 | — | — | US | disclosed |
| US-20100152172-A1 | 2,4-PYRIMIDINEDIAMINE COMPOUNDS FOR TREATING OR PREVENTING AUTOIMMUNE DISEASES | RIGEL PHARMACEUTICALS, INC. | 2010-06-17 | — | — | US | disclosed |
| US-7659280-B2 | 2,4-pyrimidinediamine compounds for treating or preventing autoimmune diseases | RIGEL PHARMACEUTICALS, INC. (US) | 2010-02-09 | — | — | US | disclosed |
| EP-1984357-A2 | 2,4-PYRIMIDINEDIAMINE COMPOUNDS FOR TREATING OR PREVENTING AUTOIMMUNE DISEASES | Rigel Pharmaceuticals, Inc. (US) | 2008-10-29 | — | — | EP | disclosed |
| WO-2007120980-A2 | 2,4-PYRIMIDINEDIAMINE COMPOUNDS FOR TREATING OR PREVENTING AUTOIMMUNE DISEASES | RIGEL PHARMACEUTICALS, INC. (US) | 2007-10-25 | — | — | WO | disclosed |
| WO-2007120980-A2 | 2,4-PYRIMIDINEDIAMINE COMPOUNDS FOR TREATING OR PREVENTING AUTOIMMUNE DISEASES | RIGEL PHARMACEUTICALS, INC. (US) | 2007-10-25 | — | — | WO | disclosed |
| US-20070197782-A1 | 2,4-PYRIMIDINEDIAMINE COMPOUNDS FOR TREATING OR PREVENTING AUTOIMMUNE DISEASES | RIGEL PHARMACEUTICALS, INC. | 2007-08-23 | — | — | US | disclosed |
| US-20070197782-A1 | 2,4-PYRIMIDINEDIAMINE COMPOUNDS FOR TREATING OR PREVENTING AUTOIMMUNE DISEASES | RIGEL PHARMACEUTICALS, INC. | 2007-08-23 | — | — | US | disclosed |
| US-20070197782-A1 | 2,4-PYRIMIDINEDIAMINE COMPOUNDS FOR TREATING OR PREVENTING AUTOIMMUNE DISEASES | RIGEL PHARMACEUTICALS, INC. | 2007-08-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070197782-A1 | 2,4-PYRIMIDINEDIAMINE COMPOUNDS FOR TREATING OR PREVENTING AUTOIMMUNE DISEASES | TPMT, SSB, HLA-DRB1 | SYK 1651/4885EGFR 4464/4885ITK 3067/4885 |
| US-20100152172-A1 | 2,4-PYRIMIDINEDIAMINE COMPOUNDS FOR TREATING OR PREVENTING AUTOIMMUNE DISEASES | TPMT, SSB, HLA-DRB1 | SYK 1651/4885EGFR 4464/4885ITK 3067/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.