Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC2A1 | P11166 | 5/20 | 0.61 |
| ▸ | POLB | P06746 | 2/20 | 0.61 |
| ▸ | RAD52 | P43351 | 2/20 | 0.61 |
| ▸ | NPC1 | O15118 | 1/20 | 0.61 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.61 |
| ▸ | RAB9A | P51151 | 1/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.61 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.61 |
| ▸ | CACNA2D1 | P54289 | 1/20 | 0.61 |
| ▸ | ACHE | P22303 | 7/20 | 0.57 |
| ▸ | BCHE | P06276 | 2/20 | 0.57 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13832351 | 0.90 | SLC2A1 (0.51) | SLC2A1POLBRAD52NPC1APOBEC3A | |
| SCHEMBL13832412 | 0.90 | KMT2A (0.51) | SLC2A1POLBRAD52NPC1APOBEC3A | |
| SCHEMBL13832346 | 0.90 | KMT2A (0.51) | SLC2A1POLBRAD52NPC1APOBEC3A | |
| SCHEMBL13832350 | 0.89 | KMT2A (0.50) | SLC2A1POLBRAD52NPC1APOBEC3A | |
| SCHEMBL13741126 | 0.82 | MEN1 (0.51) | KMT2AACHEBCHE | |
| SCHEMBL13832347 | 0.78 | MEN1 (0.47) | KMT2AACHEBCHE | |
| SCHEMBL13832416 | 0.78 | ACHE (0.42) | CACNA2D1ACHEBCHE | |
| SCHEMBL13832353 | 0.78 | MEN1 (0.48) | KMT2AACHEBCHE | |
| SCHEMBL13832354 | 0.78 | MEN1 (0.48) | KMT2AACHEBCHE | |
| SCHEMBL15745502 | 0.78 | MEN1 (0.63) | POLBNPC1RAB9AKMT2AACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10544100-B2 | Autophagy inhibitors | TRANSLATIONAL GENOMICS RESEARCH INSTITUTE (US) | 2020-01-28 | — | — | US | disclosed |
| US-20170000784-A1 | Autophagy Inhibitors | VAN ANDEL RESEARCH INSTITUTE | 2017-01-05 | — | — | US | disclosed |
| US-20170000784-A1 | Autophagy Inhibitors | VAN ANDEL RESEARCH INSTITUTE | 2017-01-05 | — | — | US | disclosed |
| US-20160137607-A1 | Autophagy Inhibitors | VAN ANDEL RESEARCH INSTITUTE | 2016-05-19 | — | — | US | disclosed |
| US-20160137607-A1 | Autophagy Inhibitors | VAN ANDEL RESEARCH INSTITUTE | 2016-05-19 | — | — | US | disclosed |
| US-9221760-B2 | Autophagy inhibitors | VAN ANDEL RESEARCH INSTITUTE (US) | 2015-12-29 | — | — | US | disclosed |
| US-9221760-B2 | Autophagy inhibitors | VAN ANDEL RESEARCH INSTITUTE (US) | 2015-12-29 | — | — | US | disclosed |
| WO-2015085229-A1 | AUTOPHAGY INHIBITORS | VAN ANDEL RESEARCH INSTITUTE (US) | 2015-06-11 | — | — | WO | disclosed |
| US-20140148451-A1 | Autophagy Inhibitors | TRANSLATIONAL GENOMICS RESEARCH INSTITUTE (US) | 2014-05-29 | — | — | US | disclosed |
| US-20140148451-A1 | Autophagy Inhibitors | TRANSLATIONAL GENOMICS RESEARCH INSTITUTE (US) | 2014-05-29 | — | — | US | disclosed |
| WO-2012154879-A2 | AUTOPHAGY INHIBITORS | VAN ANDEL RESEARCH INSTITUTE (US) | 2012-11-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10544100-B2 | Autophagy inhibitors | BECN1, ATG7, SQSTM1 | SLC2A1 2055/4885POLB 2575/4885RAD52 1883/4885 |
| US-20170000784-A1 | Autophagy Inhibitors | BRAF, HRAS, NRAS | SLC2A1 1679/4885POLB 3769/4885RAD52 1284/4885 |
| US-20140148451-A1 | Autophagy Inhibitors | BECN1, ATG7, SQSTM1 | SLC2A1 2055/4885POLB 2575/4885RAD52 1883/4885 |
| US-20160137607-A1 | Autophagy Inhibitors | BECN1, ATG7, SQSTM1 | SLC2A1 2055/4885POLB 2575/4885RAD52 1883/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.