Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.43 |
| ▸ | PARP1 | P09874 | 7/20 | 0.43 |
| ▸ | AHR | P35869 | 2/20 | 0.41 |
| ▸ | PLAU | P00749 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.39 |
| ▸ | CCKAR | P32238 | 1/20 | 0.39 |
| ▸ | PCSK9 | Q8NBP7 | 3/20 | 0.38 |
| ▸ | KDR | P35968 | 1/20 | 0.38 |
| ▸ | F2 | P00734 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7077495 | 0.82 | AHR (0.51) | PARP1AHRKDM4EHSD17B10LOXL2 | |
| SCHEMBL23632367 | 0.77 | NPC1 (0.50) | NPC1PARP1KDM4EHSD17B10 | |
| SCHEMBL28046983 | 0.75 | NPC1 (0.54) | NPC1PARP1KDM4EHSD17B10 | |
| SCHEMBL1382512 | 0.74 | CHEK2 (0.45) | PARP1AHRKDM4ELOXL2PCSK9 | |
| SCHEMBL3681824 | 0.73 | NPC1 (0.66) | NPC1PARP1KDM4EHSD17B10 | |
| SCHEMBL29990403 | 0.73 | MTNR1A (0.51) | HRH3PARP1AHRKDM4EHSD17B10 | |
| SCHEMBL3682185 | 0.72 | NPC1 (0.62) | NPC1PARP1KDM4EHSD17B10 | |
| Urea SCHEMBL28780664 | 0.70 | PLAU (0.48) | NPC1HRH3PLAUKDM4EHSD17B10 | |
| SCHEMBL1383288 | 0.70 | NPC1 (0.48) | NPC1HRH3KDM4EHSD17B10CCKAR | |
| SCHEMBL19667085 | 0.70 | NPC1 (0.47) | NPC1PARP1KDM4EHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-4831907-B2 | — | — | 2011-12-07 | — | — | JP | claimed |
| EP-1225894-A4 | FAB I INHIBITORS | SMITHKLINE BEECHAM CORP (US) | 2003-01-08 | — | — | EP | claimed |
| EP-1225894-A1 | FAB I INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2002-07-31 | — | — | EP | claimed |
| WO-2001026652-A1 | FAB I INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2001-04-19 | — | — | WO | claimed |
| EP-1225894-A4 | FAB I INHIBITORS | SMITHKLINE BEECHAM CORP (US) | 2003-01-08 | — | — | EP | disclosed |
| EP-1225894-A1 | FAB I INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2002-07-31 | — | — | EP | disclosed |
| WO-2001026652-A1 | FAB I INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2001-04-19 | — | — | WO | disclosed |