Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AHR | P35869 | 3/20 | 0.51 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.50 |
| ▸ | F2 | P00734 | 1/20 | 0.46 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.46 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.46 |
| ▸ | PCSK9 | Q8NBP7 | 6/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | PARP1 | P09874 | 1/20 | 0.43 |
| ▸ | FLT3 | P36888 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | DAO | P14920 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29990403 | 0.87 | MTNR1A (0.51) | AHRLOXL2MTNR1AMTNR1BKDM4E | |
| SCHEMBL1382512 | 0.83 | CHEK2 (0.45) | AHRLOXL2F2PCSK9KDM4E | |
| SCHEMBL1383289 | 0.82 | NPC1 (0.44) | AHRLOXL2F2PCSK9KDM4E | |
| SCHEMBL28750014 | 0.80 | TSHR (0.50) | AHRMTNR1AMTNR1BPCSK9KDM4E | |
| SCHEMBL31672301 | 0.76 | AHR (0.62) | AHRLOXL2F2MTNR1AMTNR1B | |
| SCHEMBL29403791 | 0.75 | LOXL2 (0.69) | AHRLOXL2MTNR1AMTNR1BPCSK9 | |
| SCHEMBL7134588 | 0.75 | TSHR (0.54) | KDM4EALDH1A1GAAPARP1MAPT | |
| SCHEMBL28338445 | 0.75 | LOXL2 (0.69) | AHRLOXL2MTNR1AMTNR1BPCSK9 | |
| SCHEMBL401081 | 0.75 | LOXL2 (0.69) | AHRLOXL2MTNR1AMTNR1BPCSK9 | |
| SCHEMBL630523 | 0.74 | SIRT1 (0.64) | LOXL2MTNR1AMTNR1BKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1225894-A4 | FAB I INHIBITORS | SMITHKLINE BEECHAM CORP (US) | 2003-01-08 | — | — | EP | disclosed |
| EP-1225894-A1 | FAB I INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2002-07-31 | — | — | EP | disclosed |
| WO-2001026652-A1 | FAB I INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2001-04-19 | — | — | WO | disclosed |