Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 12/20 | 0.64 |
| ▸ | PDE4A | P27815 | 8/20 | 0.64 |
| ▸ | PDE4C | Q08493 | 8/20 | 0.64 |
| ▸ | PDE4D | Q08499 | 8/20 | 0.64 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.64 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.64 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.64 |
| ▸ | PDE1A | P54750 | 1/20 | 0.64 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.64 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.64 |
| ▸ | CA1 | P00915 | 3/20 | 0.48 |
| ▸ | CA2 | P00918 | 3/20 | 0.48 |
| ▸ | SLC5A1 | P13866 | 1/20 | 0.41 |
| ▸ | SLC5A2 | P31639 | 1/20 | 0.41 |
| ▸ | KLK5 | Q9Y337 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22423385 | 0.90 | PDE4B (0.68) | PDE4BPDE4APDE4CPDE4DPDE3A | |
| SCHEMBL22847888 | 0.85 | PDE4B (0.64) | PDE4BPDE4APDE4CPDE4DPDE3A | |
| SCHEMBL5583384 | 0.84 | PDE4B (0.71) | PDE4BPDE4APDE4CPDE4DPDE3A | |
| SCHEMBL596680 | 0.84 | PDE4B (0.71) | PDE4BPDE4APDE4CPDE4DPDE3A | |
| SCHEMBL22423317 | 0.83 | PDE4B (0.44) | PDE4BPDE4APDE4CPDE4DPDE3A | |
| SCHEMBL595583 | 0.81 | PDE4B (0.71) | PDE4BPDE4APDE4CPDE4DPDE3A | |
| SCHEMBL5583250 | 0.81 | PDE4B (0.71) | PDE4BPDE4APDE4CPDE4DPDE3A | |
| Crisaborole SCHEMBL595261 | 0.78 | PDE4B (1.00) | PDE4BPDE4APDE4CPDE4DPDE3A | |
| SCHEMBL12488160 | 0.78 | PDE4B (0.64) | PDE4BPDE4APDE4CPDE4DPDE3A | |
| Crisaborole SCHEMBL5583372 | 0.78 | PDE4B (1.00) | PDE4BPDE4APDE4CPDE4DPDE3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210070779-A1 | BORON-CONTAINING SMALL MOLECULES AS ANTI-INFLAMMATORY AGENTS | ANACOR PHARMACEUTICALS INC (US) | 2021-03-11 | — | — | US | disclosed |
| US-20210070779-A1 | BORON-CONTAINING SMALL MOLECULES AS ANTI-INFLAMMATORY AGENTS | ANACOR PHARMACEUTICALS INC (US) | 2021-03-11 | — | — | US | disclosed |
| US-20200207789-A1 | BORON-CONTAINING SMALL MOLECULES AS ANTI-INFLAMMATORY AGENTS | ANACOR PHARMACEUTICALS INC (US) | 2020-07-02 | — | — | US | disclosed |
| US-20200207789-A1 | BORON-CONTAINING SMALL MOLECULES AS ANTI-INFLAMMATORY AGENTS | ANACOR PHARMACEUTICALS INC (US) | 2020-07-02 | — | — | US | disclosed |
| US-20180291040-A1 | Boron-Containing Small Molecules As Anti-Inflammatory Agents | ANACOR PHARMACEUTICALS INC (US) | 2018-10-11 | — | — | US | disclosed |
| US-20160200743-A1 | BORON-CONTAINING SMALL MOLECULES AS ANTI-INFLAMMATORY AGENTS | ANACOR PHARMACEUTICALS, INC. | 2016-07-14 | — | — | US | disclosed |
| US-20160200743-A1 | BORON-CONTAINING SMALL MOLECULES AS ANTI-INFLAMMATORY AGENTS | ANACOR PHARMACEUTICALS, INC. | 2016-07-14 | — | — | US | disclosed |
| WO-2015042532-A1 | BORON-CONTAINING SMALL MOLECULES AS ANTI-INFLAMMATORY AGENTS | ANACOR PHARMACEUTICALS, INC. (US) | 2015-03-26 | — | — | WO | disclosed |
| WO-2015042532-A1 | BORON-CONTAINING SMALL MOLECULES AS ANTI-INFLAMMATORY AGENTS | ANACOR PHARMACEUTICALS, INC. (US) | 2015-03-26 | — | — | WO | disclosed |
| US-8722917-B2 | Boron-containing small molecules | ANACOR PHARMACEUTICALS, INC. (US) | 2014-05-13 | — | — | US | disclosed |
| US-20120289686-A1 | BORON-CONTAINING SMALL MOLECULES | ANACOR PHARMACEUTICALS, INC. (US) | 2012-11-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160200743-A1 | BORON-CONTAINING SMALL MOLECULES AS ANTI-INFLAMMATORY AGENTS | NFKBIA, LITAF, TNF | PDE4B 855/4885PDE4A 1121/4885PDE4C 1792/4885 |
| US-20210070779-A1 | BORON-CONTAINING SMALL MOLECULES AS ANTI-INFLAMMATORY AGENTS | NFKBIA, TNF, LITAF | PDE4B 731/4885PDE4A 1005/4885PDE4C 1696/4885 |
| US-20200207789-A1 | BORON-CONTAINING SMALL MOLECULES AS ANTI-INFLAMMATORY AGENTS | NFKBIA, TNF, LITAF | PDE4B 731/4885PDE4A 1005/4885PDE4C 1696/4885 |
| US-20120289686-A1 | BORON-CONTAINING SMALL MOLECULES | ETF1, POLR1C, DPM1 | PDE4B 4444/4885PDE4A 4397/4885PDE4C 4585/4885 |
| US-20180291040-A1 | Boron-Containing Small Molecules As Anti-Inflammatory Agents | NFKBIA, TNF, LITAF | PDE4B 731/4885PDE4A 1005/4885PDE4C 1696/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.