Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Crisaborole. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B known ✓ | Q07343 | 19/20 | 1.00 |
| ▸ | PDE4A known ✓ | P27815 | 14/20 | 1.00 |
| ▸ | PDE4C known ✓ | Q08493 | 14/20 | 1.00 |
| ▸ | PDE4D known ✓ | Q08499 | 14/20 | 1.00 |
| ▸ | CHRM1 | P11229 | 1/20 | 1.00 |
| ▸ | ADRA1A | P35348 | 1/20 | 1.00 |
| ▸ | PDE1A | P54750 | 1/20 | 1.00 |
| ▸ | PDE3B | Q13370 | 1/20 | 1.00 |
| ▸ | PDE7A | Q13946 | 1/20 | 1.00 |
| ▸ | PDE3A | Q14432 | 1/20 | 1.00 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Crisaborole SCHEMBL29352751 | 1.00 | PDE4B (1.00) | PDE4BPDE4APDE4CPDE4DCHRM1 | |
| Crisaborole SCHEMBL5583372 | 1.00 | PDE4B (1.00) | PDE4BPDE4APDE4CPDE4DCHRM1 | |
| SCHEMBL23513127 | 0.91 | PDE4B (1.00) | PDE4BPDE4APDE4CPDE4DCHRM1 | |
| SCHEMBL12431101 | 0.90 | PDE4B (0.82) | PDE4BPDE4APDE4CPDE4DCHRM1 | |
| SCHEMBL2529609 | 0.89 | PDE4B (0.80) | PDE4BPDE4APDE4CPDE4DCHRM1 | |
| SCHEMBL595831 | 0.89 | PDE4B (0.80) | PDE4BPDE4APDE4CPDE4DCHRM1 | |
| SCHEMBL5583333 | 0.89 | PDE4B (0.80) | PDE4BPDE4APDE4CPDE4DCHRM1 | |
| SCHEMBL5583207 | 0.88 | PDE4B (1.00) | PDE4BPDE4APDE4CPDE4DCHRM1 | |
| SCHEMBL595173 | 0.88 | PDE4B (1.00) | PDE4BPDE4APDE4CPDE4DCHRM1 | |
| SCHEMBL2527257 | 0.86 | PDE4B (0.75) | PDE4BPDE4APDE4CPDE4DCHRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 405 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240358728-A1 | BORON CONTAINING SMALL MOLECULES AS ANTI-INFLAMMATORY AGENTS | ANACOR PHARMACEUTICALS, LLC (US) | 2024-10-31 | — | — | US | claimed |
| US-20230008130-A1 | BORON CONTAINING SMALL MOLECULES AS ANTI-INFLAMMATORY AGENTS | ANACOR PHARMACEUTICALS, INC. (US) | 2023-01-12 | — | — | US | claimed |
| US-11447506-B2 | Crystal forms of crisaborole in free form and preparation method and use thereof | ANACOR PHARMACEUTICALS, INC. (US) | 2022-09-20 | — | — | US | claimed |
| CN-114053280-A | Application of phosphodiesterase inhibitor or pharmaceutical composition thereof in preparation of medicine for treating novel coronavirus pneumonia | 南方科技大学 | 2022-02-18 | — | — | CN | claimed |
| WO-2022027180-A1 | APPLICATION OF PHOSPHODIESTERASE INHIBITOR OR PHARMACEUTICAL COMPOSITION THEREOF IN PREPARATION OF DRUG FOR TREATING NOVEL CORONAVIRUS PNEUMONIA | 南方科技大学 | 2022-02-10 | — | — | WO | claimed |
| EP-3831389-A1 | TOPICAL PHARMACEUTICAL FORMULATIONS COMPRISING CRISABOROLE FOR TREATING INFLAMMATORY-RELATED CONDITIONS | Anacor Pharmaceuticals, Inc (US) | 2021-06-09 | — | — | EP | claimed |
| EP-3424932-B1 | BORONOPHTHALIDES FOR THERAPEUTIC USE | ANACOR PHARMACEUTICALS INC (US) | 2021-04-07 | — | — | EP | claimed |
| US-20210002307-A1 | Crystal Forms of Crisaborole In Free Form And Preparation Method And Use Thereof | ANACOR PHARMACEUTICALS, INC. (US) | 2021-01-07 | — | — | US | claimed |
| US-20210000847-A1 | BORON CONTAINING SMALL MOLECULES AS ANTI-INFLAMMATORY AGENTS | ANACOR PHARMACEUTICALS, INC. (US) | 2021-01-07 | — | — | US | claimed |
| EP-3383363-B1 | TOPICAL PHARMACEUTICAL FORMULATIONS FOR TREATING INFLAMMATORY-RELATED CONDITIONS | ANACOR PHARMACEUTICALS INC (US) | 2021-01-06 | — | — | EP | claimed |
| WO-2017102565-A1 | PHARMACEUTICAL COMPOSITION COMPRISING A FULVIC ACID AND AT LEAST ONE BORON-CONTAINING COMPOUND | DOBMEYER RITA (CH) | 2017-06-22 | — | — | WO | claimed |
| WO-2017093857-A1 | TOPICAL PHARMACEUTICAL FORMULATIONS FOR TREATING INFLAMMATORY-RELATED CONDITIONS | ANACOR PHARMACEUTICALS, INC. (US) | 2017-06-08 | — | — | WO | claimed |
| US-20170152273-A1 | Topical Pharmaceutical Formulations For Treating Inflammatory-Related Conditions | ANACOR PHARMACEUTICALS INC. (US) | 2017-06-01 | — | — | US | claimed |
| US-20150216885-A1 | BORON-CONTAINING SMALL MOLECULES AS ANTI-INFLAMMATORY AGENTS | ANACOR PHARMACEUTICALS, LLC | 2015-08-06 | — | — | US | claimed |
| EP-2343304-B1 | Biocidal boronophthalide compounds | ANACOR PHARMACEUTICALS INC (US) | 2015-06-10 | — | — | EP | claimed |
| US-20130316979-A1 | BORON-CONTAINING SMALL MOLECULES AS ANTI-INFLAMMATORY AGENTS | ANACOR PHARMACEUTICALS, INC. (US) | 2013-11-28 | — | — | US | claimed |
| US-8039451-B2 | Boron-containing small molecules | ANACOR PHARMACEUTICALS, INC. (US) | 2011-10-18 | — | — | US | claimed |
| EP-2343304-A1 | Biocidal boronophthalide compounds | Anacor Pharmaceuticals, Inc. (US) | 2011-07-13 | — | — | EP | claimed |
| US-20100190748-A1 | BORON-CONTAINING SMALL MOLECULES | ANACOR PHARMACEUTICALS, INC. (US) | 2010-07-29 | — | — | US | claimed |
| US-20070293457-A1 | BORON-CONTAINING SMALL MOLECULES AS ANTI-INFLAMMATORY AGENTS | ANACOR PHARMACEUTICALS, LLC | 2007-12-20 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (10 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230008130-A1 | BORON CONTAINING SMALL MOLECULES AS ANTI-INFLAMMATORY AGENTS | NFKBIA, LITAF, LRBA | PDE4B 948/4885PDE4A 1385/4885PDE4C 2189/4885 |
| US-20150216885-A1 | BORON-CONTAINING SMALL MOLECULES AS ANTI-INFLAMMATORY AGENTS | NFKBIA, LITAF, TNF | PDE4B 1058/4885PDE4A 1336/4885PDE4C 2209/4885 |
| US-20240358728-A1 | BORON CONTAINING SMALL MOLECULES AS ANTI-INFLAMMATORY AGENTS | NFKBIA, LITAF, LRBA | PDE4B 948/4885PDE4A 1385/4885PDE4C 2189/4885 |
| US-20210002307-A1 | Crystal Forms of Crisaborole In Free Form And Preparation Method And Use Thereof | FGB, CSTB, UGT2B17 | PDE4B 1568/4885PDE4A 2561/4885PDE4C 1759/4885 |
| US-20070293457-A1 | BORON-CONTAINING SMALL MOLECULES AS ANTI-INFLAMMATORY AGENTS | NFKBIA, LITAF, TNF | PDE4B 1058/4885PDE4A 1336/4885PDE4C 2209/4885 |
| US-11447506-B2 | Crystal forms of crisaborole in free form and preparation method and use thereof | FGB, CSTB, UGT2B17 | PDE4B 1568/4885PDE4A 2561/4885PDE4C 1759/4885 |
| US-20130316979-A1 | BORON-CONTAINING SMALL MOLECULES AS ANTI-INFLAMMATORY AGENTS | NFKBIA, LITAF, TNF | PDE4B 1058/4885PDE4A 1336/4885PDE4C 2209/4885 |
| US-20210000847-A1 | BORON CONTAINING SMALL MOLECULES AS ANTI-INFLAMMATORY AGENTS | NFKBIA, LITAF, LRBA | PDE4B 948/4885PDE4A 1385/4885PDE4C 2189/4885 |
| US-20170152273-A1 | Topical Pharmaceutical Formulations For Treating Inflammatory-Related Conditions | TSLP, ASAH2, CYSLTR2 | PDE4B 115/4885PDE4A 99/4885PDE4C 133/4885 |
| US-20100190748-A1 | BORON-CONTAINING SMALL MOLECULES | ETF1, POLR1C, DPM1 | PDE4B 4444/4885PDE4A 4397/4885PDE4C 4585/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.