SCHEMBL1383530

SCHEMBL1383530

CC(NC(=O)c1ccccc1NS(=O)(=O)c1cccc2nccnc12)c1ccccc1

nearest known ligand 0.60

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
KCNA5 P22460 5/20 0.60
ALDH1A1 P00352 2/20 0.58
KDM4E B2RXH2 1/20 0.58
HPGD P15428 1/20 0.58
HSD17B10 Q99714 1/20 0.58
KMT2A Q03164 3/20 0.56
MEN1 O00255 2/20 0.56
L3MBTL1 Q9Y468 2/20 0.48
ATM Q13315 1/20 0.48
CCKAR P32238 6/20 0.48
CCKBR P32239 6/20 0.48
POLB P06746 2/20 0.47
CTDSP1 Q9GZU7 1/20 0.47
LMNA P02545 1/20 0.47
MAPT P10636 1/20 0.47
TDP1 Q9NUW8 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1383252 0.92 KCNA5 (0.52) KCNA5ALDH1A1KDM4EHPGDHSD17B10
SCHEMBL1381729 0.92 KCNA5 (0.52) KCNA5ALDH1A1KDM4EHPGDHSD17B10
SCHEMBL5072309 0.88 KCNA5 (0.77) KCNA5ALDH1A1KDM4EHPGDHSD17B10
SCHEMBL5616178 0.88 KCNA5 (0.77) KCNA5ALDH1A1KDM4EHPGDHSD17B10
SCHEMBL5074830 0.88 KCNA5 (0.77) KCNA5ALDH1A1KDM4EHPGDHSD17B10
SCHEMBL1383536 0.84 MEN1 (0.55) KCNA5ALDH1A1HPGDHSD17B10KMT2A
SCHEMBL1889221 0.84 CCKBR (0.60) CCKARCCKBR
SCHEMBL1382499 0.83 CCKBR (0.50) KCNA5ALDH1A1KDM4EHPGDHSD17B10
SCHEMBL1383512 0.83 CCKBR (0.52) KCNA5KMT2AMEN1CCKARCCKBR
SCHEMBL12659883 0.82 L3MBTL1 (0.68) KCNA5ALDH1A1HPGDHSD17B10KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
JP-4818110-B2 2011-11-16 JP claimed