SCHEMBL1383536

SCHEMBL1383536

CNC(=O)c1ccccc1NS(=O)(=O)c1cccc2nccnc12

nearest known ligand 0.55

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 3/20 0.55
KMT2A Q03164 3/20 0.55
L3MBTL1 Q9Y468 2/20 0.54
POLB P06746 1/20 0.54
CTDSP1 Q9GZU7 1/20 0.54
SLC40A1 Q9NP59 3/20 0.53
ATM Q13315 1/20 0.52
KCNA5 P22460 1/20 0.52
MAPT P10636 2/20 0.50
HSD17B10 Q99714 1/20 0.50
CCKBR P32239 8/20 0.49
ALDH1A1 P00352 1/20 0.49
HPGD P15428 1/20 0.49
NPSR1 Q6W5P4 1/20 0.49
GAA P10253 1/20 0.47
PABPC1 P11940 1/20 0.46
EIF4H Q15056 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12659883 0.86 L3MBTL1 (0.68) MEN1KMT2AL3MBTL1POLBCTDSP1
SCHEMBL14338547 0.86 SLC40A1 (0.65) MEN1KMT2AL3MBTL1POLBCTDSP1
SCHEMBL1891388 0.85 L3MBTL1 (0.54) MEN1KMT2AL3MBTL1POLBCTDSP1
SCHEMBL1383530 0.84 KCNA5 (0.60) MEN1KMT2AL3MBTL1POLBCTDSP1
SCHEMBL1381729 0.81 KCNA5 (0.52) MEN1KMT2AL3MBTL1POLBCTDSP1
SCHEMBL1383252 0.81 KCNA5 (0.52) MEN1KMT2AKCNA5HSD17B10CCKBR
SCHEMBL12659884 0.80 POLB (0.66) MEN1KMT2APOLBSLC40A1MAPT
SCHEMBL1382888 0.79 CCKBR (0.54) CCKBRALDH1A1
SCHEMBL1382891 0.79 KDM4E (0.56) MEN1KMT2AL3MBTL1POLBATM
SCHEMBL1383512 0.78 CCKBR (0.52) MEN1KMT2AKCNA5CCKBR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
JP-4818110-B2 2011-11-16 JP claimed