Acrylonitrile

Acrylonitrile

SCHEMBL13835535

C/C(=C\CC1CO1)C(=O)O.C=CC#N.C=CC(=O)OCCCC

nearest known ligand 0.48

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Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
TSHR P16473 6/20 0.48
HPGD P15428 1/20 0.48
ALDH1A1 P00352 5/20 0.35
CYP3A4 P08684 1/20 0.35
ATM Q13315 1/20 0.35
HCAR2 Q8TDS4 3/20 0.35
SMN1; SMN2 Q16637 1/20 0.33
TP53 P04637 2/20 0.30
HIF1A Q16665 2/20 0.30
HSD17B10 Q99714 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Acrylonitrile SCHEMBL28796018 0.85 TSHR (0.56) TSHRHPGDALDH1A1CYP3A4ATM
Acrylonitrile SCHEMBL94006 0.81 ALDH1A1 (0.56) TSHRHPGDALDH1A1CYP3A4ATM
Acrylonitrile SCHEMBL195459 0.81 ALDH1A1 (0.42) TSHRHPGDALDH1A1
SCHEMBL7867905 0.80 TSHR (0.40) TSHRHPGDALDH1A1CYP3A4TP53
SCHEMBL8534061 0.79 ALDH1A1 (0.51) TSHRHPGDALDH1A1CYP3A4ATM
Methacrylic Acid SCHEMBL7573804 0.78 TSHR (0.65) TSHRHPGDALDH1A1CYP3A4ATM
Acrylonitrile SCHEMBL5833833 0.78 TSHR (0.79) TSHRHPGDALDH1A1CYP3A4ATM
Acrylonitrile SCHEMBL2146545 0.78 TSHR (0.79) TSHRHPGDALDH1A1CYP3A4ATM
Acrylic Acid Ethyl Ester SCHEMBL4844310 0.78 ALDH1A1 (0.36) TSHRHPGDALDH1A1HCAR2
SCHEMBL222966 0.77 TSHR (0.67) TSHRHPGDALDH1A1CYP3A4ATM

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20120296010-A1 ENCAPSULATING SHEET AND ELECTRONIC DEVICE NITTO DENKO CORPORATION (JP) 2012-11-22 US disclosed