Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CFD | P00746 | 2/20 | 0.44 |
| ▸ | MTNR1A | P48039 | 4/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.35 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.35 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.33 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.33 |
| ▸ | AKR1A1 | P14550 | 1/20 | 0.33 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13967350 | 0.93 | CFD (0.46) | CFDMTNR1APKMKDM4EALDH1A1 | |
| SCHEMBL13837153 | 0.86 | CFD (0.43) | CFDMTNR1APKMKDM4EALDH1A1 | |
| SCHEMBL19233878 | 0.81 | MTNR1A (0.46) | CFDMTNR1APKMKDM4EALDH1A1 | |
| Trifluoroacetic Acid SCHEMBL13837183 | 0.74 | KDM4E (0.43) | CFDKDM4EALDH1A1RAB9ASMN1; SMN2 | |
| Trifluoroacetic Acid SCHEMBL15542143 | 0.72 | CFD (0.42) | CFDMTNR1AKDM4EALDH1A1RAB9A | |
| Trifluoroacetic Acid SCHEMBL12481205 | 0.71 | CFD (0.42) | CFDMTNR1APKMKDM4EALDH1A1 | |
| SCHEMBL12480373 | 0.71 | ALDH1A1 (0.56) | PKMKDM4EALDH1A1HPGDTSHR | |
| SCHEMBL12480545 | 0.71 | CFD (0.42) | CFDKDM4EALDH1A1TSHRSMN1; SMN2 | |
| Trifluoroacetic Acid SCHEMBL12480789 | 0.70 | KDM4E (0.50) | CFDKDM4EALDH1A1TSHRSMN1; SMN2 | |
| Trifluoroacetic Acid SCHEMBL13837583 | 0.70 | KDM4E (0.50) | CFDKDM4EALDH1A1TSHRPTGDR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2661433-B1 | INDOLE COMPOUNDS OR ANALOGUES THEREOF USEFUL FOR THE TREATMENT OF AGE-RELATED MACULAR DEGENERATION (AMD) | NOVARTIS AG (CH) | 2017-08-16 | — | — | EP | disclosed |
| US-9085555-B2 | Complement pathway modulators and uses thereof | NOVARTIS AG (CH) | 2015-07-21 | — | — | US | disclosed |
| US-20120295884-A1 | Complement pathway modulators and uses thereof | NOVARTIS AG (CH) | 2012-11-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120295884-A1 | Complement pathway modulators and uses thereof | C5, C3AR1, C9 | CFD 9/4885MTNR1A 677/4885PKM 1477/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.