Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR4 | Q13639 | 20/20 | 0.74 |
| ▸ | HTR2A | P28223 | 8/20 | 0.71 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.69 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL3220552 | 0.99 | HTR4 (0.74) | HTR4HTR2AKCNH2 | |
| SCHEMBL1376077 | 0.94 | HTR4 (0.73) | HTR4HTR2AKCNH2 | |
| Hydrochloric Acid SCHEMBL3260270 | 0.93 | HTR4 (0.73) | HTR4HTR2AKCNH2 | |
| SCHEMBL1377419 | 0.93 | HTR4 (0.72) | HTR4HTR2AKCNH2 | |
| Hydrochloric Acid SCHEMBL3218672 | 0.92 | HTR4 (0.73) | HTR4HTR2AKCNH2 | |
| SCHEMBL1381802 | 0.92 | HTR4 (0.66) | HTR4HTR2AKCNH2 | |
| Hydrochloric Acid SCHEMBL3209795 | 0.91 | HTR4 (0.65) | HTR4HTR2AKCNH2 | |
| SCHEMBL1381230 | 0.91 | GSK3B (0.67) | HTR4HTR2AKCNH2 | |
| SCHEMBL1379554 | 0.90 | HTR4 (0.75) | HTR4HTR2AKCNH2 | |
| Hydrochloric Acid SCHEMBL3216294 | 0.90 | GSK3B (0.66) | HTR4HTR2AKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-4724651-B2 | — | — | 2011-07-13 | — | — | JP | claimed |
| EP-1594859-B1 | INDAZOLAMIDES WITH ANALGESIC ACTIVITY | ACRAF (IT) | 2010-06-23 | — | — | EP | claimed |
| US-7632849-B2 | N3-((1-(2-Oxo-2-(phenylamino)ethyl)-4-piperidyl)methyl)- 1-(1-methylethyl)-1H-indazole-3-carboxamide; antiarthritic agents; rheumatic diseases; osteoarthritis; fibromyaleia;anticarcinogenic agents, pain; neuropathic pain; immunoincompetance; trauma; antiischemic agents; multiple sclerosis | AZIENDE CHIMICHE RIUNITE ANGELINI FRANCESCO A.C.R.A.F. S.P.A. (IT) | 2009-12-15 | — | — | US | claimed |
| US-20060052417-A1 | Indazolamides with analgesic activity | AZIENDE CHIMICHE RIUNITE ANGELINI FRANCESCO A.C.R.A.F. S.P.A. (IT) | 2006-03-09 | — | — | US | claimed |
| EP-1594859-A1 | INDAZOLAMIDES WITH ANALGESIC ACTIVITY | AZIENDE CHIMICHE RIUNITE ANGELINI FRANCESCO A.C.R.A.F. S.p.A. (IT) | 2005-11-16 | — | — | EP | claimed |
| WO-2004074275-A1 | INDAZOLAMIDES WITH ANALGESIC ACTIVITY | AZIENDE CHIMICHE RIUNITE ANGELINI FRANCESCO A.C.R.A.F. S.P.A. (IT) | 2004-09-02 | — | — | WO | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060052417-A1 | Indazolamides with analgesic activity | P2RX7, P2RX3, P2RX1 | HTR4 841/4885HTR2A 859/4885KCNH2 30/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.